Nisshinbo Industries, Inc.

Shiseido Company, Limited

The General Hospital Corporation

Other

University School of Medicine

Satoshi Amano

Hideshi Tomita

Takahiko Ito

Yasuo Imashiro

Tomoki Nakamura

Hirotada Fukunishi

Masaru Suetsugu

Norimasa Nakamura

Shunsuke Iriyama

Toshio Nishiyama

Osamu Suzuki

Toshio Suzuki

Robert E Burgeson

Teruhiko Ohnuma

Kazuo Saito

Ikuo Takahashi

Gen Masuda

Jiro Kishimoto

Shun Hasegawa

Takeshi Arai

Takahiko Itoh

Shinji Inomata

Kenichi Umishio

Naoto Hanyu

Chieko Mizumoto

Makoto Tsunenaga

Takuya Hiruma

Masato Iino

Eijiro Adachi

Ken Kusakari

Ritsuko Ehama

Chie Yasuda

Seiji Satoh

Yukiko Matsunaga

Shoji Kuroyama

Nobuyuji Shioya

Robert Eugene Burgeson

Provided are a counseling method and counseling device which present a skincare advice appropriate to a user. The counseling device includes an obtaining unit that obtains genetic information representing a result of a genetic test on a user and stratum corneum information representing a result of a stratum corneum test on the user; a skin constitution determining unit that determines skin constitution of the user, based on the genetic information; a skin capability determining unit that determines skin capability representing a skin condition of the user, based on the stratum corneum information; an identifying unit that identifies a skincare advice and/or a cosmetic to be proposed to the user, based on the skin constitution and the skin capability; and a presenting unit that presents counseling information including information on the skincare advice and/or cosmetic to the user.

Counseling method and counseling device

A heparanase activity inhibitor containing, as an active ingredient, a 4-alkylresorcinol represented by formula (I): wherein R represents a C1-6 linear or branched alkyl group.

Heparanase activity inhibitor, wrinkle improving agent containing same, and pharmaceutical composition

A heparanase activity inhibitor comprising, as an active ingredient, a cyclic carboxamide derivative represented by formula (I): wherein n is an integer of 1 to 3, Ris hydrogen or a C1-6 hydrocarbon group optionally substituted with hydroxyl, X is &#x2014;CH&#x2014; or a group represented by &#x2014;N(R)&#x2014;, and Ris hydrogen or a C1-6 hydrocarbon group optionally substituted with hydroxyl,or a salt thereof.

Heparanase activity inhibitor

A method for reducing the occurrence of wrinkles in skin caused by aging by promoting the growth of fibroblasts, which have a declined cellular proliferative potential due to aging or adverse affects from ultraviolet light or active oxygen. The method includes the steps of providing an agent that contains a yeast extract and a safflower extract as effective constituents, and applying the agent to skin to promote the growth of fibroblasts.

Method for growing fibroblasts

A method for production of artificial skin by administering matrix metalloproteinase inhibitor or matrix metalloproteinase inhibitor and matrix protein production promoting agent. The matrix metalloproteinase inhibitor is N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide hydrochloride.

Method of production of artificial skin

The invention provides methods of evaluating a treatment for its effect on skin. The invention also provides non-human transgenic animals, e.g., mice, having a reporter gene coupled to a skin-metabolism promoter.

Method for evaluating a compound for its effect on skin

Disclosed are compositions for promoting the production of laminin 5 in epidermic cells which contain a lysophospholipid having a C fatty acid residue or a preparation derived from soybeans as an active ingredient and which can be used in the fields of cosmetics and dermatology. These compositions may be used especially for the purpose of potentiating the skin.

Agents promoting laminin production in skin cells

A modified carbodiimide resin obtainable by reacting a carbodiimide resin comprising a repeating unit represented by the general formula: &mdash;(NCN&mdash;R )- wherein R represents a divalent organic group, with an aromatic diamine represented by the general formula: H N&mdash;R &mdash;NH wherein R represents a divalent organic group having a benzene ring, and a thermosetting resin composition comprising the modified carbodiimide resin and an epoxy resin.

Thermosetting resin composition

A metal material subjected to a treatment for seizure prevention is provided. The metal material includes a metal base material and a film formed thereon, the film being composed of a carbodiimide group-containing resin obtained from an aromatic polyisocyanate or of a mixture of said carbodiimide group-containing resin and a lubricant. A method for producing a metal material subjected to a treatment for seizure prevention is also provided. The method includes coating, on a metal base material, a carbodiimide group-containing resin obtained from an aromatic polyisocyanate or a mixture of said carbodiimide group-containing resin and a lubricant, and then subjecting the coated metal base material to a heat treatment at a temperature of 120&deg; C. or higher.

Metal material subjected to treatment for seizure prevention and method for production thereof

The present invention provides a method of adhering adherends, including (i) providing at least two adherends at least one of which is made of a flexible material, and (ii) joining the adherends together to form a structure using a heat-resistant adhesive composition containing mainly 1) a polycarbodiimide resin and an epoxy resin, or 2) a polycarbodiimide resin, an epoxy resin and a curing agent for the polycarbodiimide resin, or 3) a polycarbodiimide resin, an epoxy resin and a curing agent for the epoxy resin. The heat-resistant adhesive composition can be applied under mild conditions, and the resultant structure has excellent heat resistance and chemical resistance, and has superior adhesion strength particularly at high temperatures.

Method of adhering adherends

A modified carbodiimide resin obtainable by reacting a carbodiimide resin comprising a repeating unit represented by the general formula: &mdash;(NCN&mdash;R,)&mdash; wherein R,represents a divalent organic group, with an aromatic diamine represented by the general formula: H,N&mdash;R,&mdash;NH,wherein R,represents a divalent organic group having a benzene ring, and a thermosetting resin composition comprising the modified carbodiimide resin and an epoxy resin.

A resin composition for use in a liquid sealant, which is composed mainly of an epoxy compound, an epoxy resin curing agent and a polycarbodiimide resin, the proportion of the polycarbodiimide resin being 0.1 to 10 parts by weight relative to 100 parts by weight of the epoxy compound, and which is liquid or fluid at ordinary temperature. The liquid sealant comprises a resin composition which is composed mainly of an epoxy compound and a polycarbodiimide resin, the proportion of the polycarbodiimide resin being 0.1 to 10 parts by weight relative to 100 parts by weight of the epoxy compound, an epoxy resin curing agent, an epoxy resin curing accelerator and an inorganic powder. The sealant is liquid or fluid at ordinary temperature.

Resin composition for use in sealant and liquid sealant using the resin composition

The present invention provides an insulating material for the enameled wire of a motor of a refrigeration compressor using hydrofluorocarbons as the refrigerant and, as the refrigerating machine oil, a synthetic lubricating oil having at least one ester bond in a molecule such as ester-modified polyoxyalkylene glycol type, ester-modified ether type or ester type, which insulating material contains a compound having at least one carbodiimide group. This insulating material for the enameled wire of a motor of a refrigeration compressor, which is free from the above-mentioned problems of the prior art, which can prevent the surface deterioration or peeling (blister or cracking) etc. seen in the conventional insulating material used for covering the enameled wire (e.g. magnet wire) of a refrigeration compressor, caused by a mixture of the hydrofluorocarbons and the synthetic lubricating oil both used in the compressor, which invites neither insulation breakdown nor reduction in insulation and has improved resistances to said substitute flon and said synthetic lubricating oil, and which further can impart deterioration resistance to the synthetic lubricating oil.

Insulating material for enameled wire of motor of refrigeration

The use of laminin-5 to promote formation of basement membrane and to form skin equivalents and to improve grafting of keratinocyte sheets.

Growing community of inventors

Tokyo, Japan

Satoshi Amano