Daiichi Sankyo Company, Limited

Tokyo Juki Industrial Co., Ltd.

Satoru Yasuda

Takeshi Masuda

Daisuke Okajima

Hideo Asao

Hiroshi Kuga

Hiromi Ishibashi

Kei Enomoto

Masako Soma

Junko Kawamura

A protein that recognizes a drug moiety of an antibody-drug conjugate in which a drug represented by the following formula is conjugated to an antibody via a linker, and a method for quantifying the concentration in plasma of an antibody-drug conjugate in a mammal to which the antibody-drug conjugate has been administered, by using the protein, and a method for identifying a tissue distribution of an antibody-drug conjugate.

Protein recognizing drug moiety of antibody-drug conjugate

A method for identifying a subject to whom a medicament containing an anti-hTROP2 antibody is to be given, wherein the subject is a human patient suffering from a cancer, comprising: obtaining a biological sample from the human patient diagnosed as suffering from a cancer; evaluating an amount of expression of the hTROP2 gene at mRNA level in the biological sample; evaluating an amount of expression of the SLFN11 gene at mRNA level in the biological sample, wherein the biological sample is one that is determined to have a high amount of expression of the hTROP2 gene; and identifying the human patient who provided the biological sample, wherein the biological sample is one that is determined to have a high amount of expression of the SLFN11 gene, as a subject to whom a medicament containing an anti-hTROP2 antibody is to be given.

Sensitivity marker for antibody-drug conjugate

The invention relates to a sewing device which includes a sewing machine fixedly provided on a horizontal top surface of a bench, a fabric transfer mechanism for holding and making a fabric movable on the tip surface of the bench between a first position and a second position with a machine sewing portion being interposed therebetween and a pulse motor interlocked with the fabric transfer mechanism to move the mechanism. The machine sewing is performed during the movement of the fabric transfer mechanism from the first position to the second position. The device further includes a memory portion for storing length data of a plurality of seam lines to be stitched on the fabrics, the seam lines being different in length from one another. The device also includes a controller storing instruction data for driving a pulse motor by pulse numbers necessary for reciprocating the fabric transfer mechanism between the first and the second positions, repeating the length data of the memory portion based on the order data in association with the movement of the fabric transfer mechanism from the second position to the first position, and driving and stopping the sewing machine during a time period suitable for forming the seam lines in accordance with the length data during the movement of the fabric transfer mechanism from the first position to the second position.

Piping sewing device

Growing community of inventors

Tokyo, Japan

Satoru Yasuda