Daicel Chemical Industries, Ltd.

Satoru Nose

Takeshi Hamatani

Kieko Sano

Noritsugu Yamasaki

Mitsuru Ohno

Syu-ichi Yamagiwa

A novel monomethyl malonate derivative is represented by following Formula (I): wherein X is a halogen atom; and Me is methyl group. This compound can be prepared by the steps of (A) reacting a benzyl halide derivative represented by following Formula (II): wherein X and Y may be the same as or different from each other and are each a halogen atom, with dimethyl malonate in the presence of a base to yield a dimethyl malonate derivative represented by following Formula (III): wherein X and Me have the same meanings as defined above; and (B) hydrolyzing the dimethyl malonate derivative of Formula (III). The compound is useful in the production of an indanonecarboxylic acid ester having a halogen atom on the indanone ring.

Malonic acid monomethyl derivatives and production process thereof

Disclosed is a novel acid halide derivative represented by Formula (I):wherein X and Y may be the same or different and are each a halogen atom; and R is a lower alkyl group. By cyclizing the acid halide derivative of Formula (I) in the presence of a catalyst, an indanonecarboxylic acid ester represented by Formula (VI):wherein X and R are as defined above, is produced. Such indanonecarboxylic acid esters are useful as intermediates for insecticides.

Acid halide derivatives, their production, and production of indanonecarboxylic acid esters using the same

6-Alkoxycarbonylmethyl-4H-1,3-dioxin-4-one derivatives are produced by reacting a 6-halomethyl-4H-1,3-dioxin-4-one derivative with carbon monoxide and an alcohol or water, and 3-oxopentanedicarboxylic acid esters are further produced by reacting the above derivatives with an alcohol or water. Such a process can produce 3-oxopentanedicarboxylic acid esters in an easy and simple and efficient manner.

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Arai, Japan

Satoru Nose