Otsuka Pharmaceutical Company, Limited

Satoru Nakai

Yoshikatsu Hirai

Koutoku Aihara

Kazuyoshi Kawai

Seiji Akamatsu

Hiroyuki Ichikawa

Michiaki Tominaga

Masakazu Adachi

Fumio Saito

Mayumi Kaneta

Hitomi Mori

Yeong-Man Hong

Yasuo Yanagihara

Setsuko Takegata

Yoshikazu Kikumoto

Kiyoshi Ishii

Takashi Kamogashira

Yoshihiro Masui

Hideo Tanaka

Masayuki Takahashi

Tsutomu Nishida

Hitomi Iba

Tadamitsu Kishimoto

Yuichi Yamamura

Yasukazu Ohmoto

Keiko Mizuno

Naomi Kouno

Tohru Hirato

Yasue Konishi

Yoshikatu Hirai

A homogeneous interleukin 1.beta. (IL-1.beta.), its derivative having a modified amino acid sequence of IL-1.beta., a gene coding for said derivative, medical composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.beta. and the derivative.

IL-1.beta. and derivatives thereof and drugs

An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) and salts thereof.

Apoptosis regulating composition

An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.

This invention provides an anti-tumor agent and a method for treating a tumor wherein gamma-interferon and interleukin-1 are used as active ingredients.

Method of treating colon, renal, and lung carcinomas with

DNA encoding interleukin IL-1.beta. mutant

This invention provides medical uses of a M-CSF, particularly a method and composition for treating inflammatory disease and allergy using natural M-CSF or recombinant M-CSF or the derivatives thereof.

Methods of treating allergies with M-CSF

The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a Il-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.

IL-1.alpha. derivatives

Apoptosis regulating compostion

A drug for preventing and curing liver diseases comprising at least one member selected from interleukin-1 and its derivatives as an effective component. The drug meaningfully suppresses GOT and GPT activities in blood which are markers of liver diseases, and also suppresses symptoms such as choloplania.

Use of interleukin-1 (IL-1) to inhibit development of hepatitis

Methods are disclosed for promoting production of colony stimulating factor and inhibiting growth of Meth A tumor cells comprising administering a pharmaceutically effective amount of modified IL-1.alpha. to a subject.

Methods of use of IL-1.alpha.

Apoptosis regulating compositions each comprising a member selected from a series of carbostyril derivatives and salts thereof, inclusive of carbostyril derivatives of general formula (1) ##STR1## and salts thereof, as an active ingredient are provided. The apoptosis regulating compositions of the invention are of use as anticancer agents, antiretrovirus agents, therapeutic agents for autoimmune diseases, therapeutic agents for thrombocytopenia, therapeutic agents for Alzheimer's disease, therapeutic agents for diseases of the liver, and cancer metastasis inhibitors, among others.

An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.

Growing community of inventors

Tokushima-ken, Japan

Satoru Nakai