Daiichi Pharmaceutical Co., Ltd.

Daiichi Sankyo Company, Limited

National Institute of Information and Communications Technology, Incorporated Administrative Agency

Satoru Miyauchi

Hideki Kubota

Makoto Takemura

Hisashi Takahashi

Masanori Saito

Kenichi Kimura

Masayuki Ito

Rie Miyauchi

Youichi Kimura

Hitoshi Ohki

Kazuyuki Sugita

Kayoko Motoki

Takanori Yasukouchi

Hideo Eda

Hitoshi Iimori

Masahiko Matsuo

The present invention relates to a novel compound having an effect of inhibiting production/secretion of &#x3b2;-amyloid protein. The present invention provides a compound represented by the general formula (1): 

Pyridylmethylsulfone derivative

Provided is a compound capable of inhibiting production or secretion of &#x3b2; amyloid protein. A compound represented by the following formula (1): (wherein, Rrepresents a heterocyclic group which may have a substituent, Rrepresents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, Rrepresents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, Rrepresents a hydrogen atom or a Calkyl group, and X represents &#x2014;S&#x2014;, &#x2014;SO&#x2014; or &#x2014;SO&#x2014;); an N-oxide or S-oxide thereof; a salt thereof; or a solvate thereof; and a medicament containing any of them.

Heterocyclic methyl sulfone derivative

Provided are novel compounds having an inhibitory activity against production or secretion of &#x3b2;-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them.

&#x3b2;-amyloid protein production/secretion inhibitor

A method for processing magnetic resonance imaging image information is characterized by that a magnetic resonance spectral intensity value is measured at each of a plurality of measuring points that are arranged at predetermined intervals along a lengthwise direction, a crosswise direction and a height direction on an object to be measured and several kinds of magnetic resonance imaging image information as a set of the magnetic resonance spectral intensity values measured at the measuring point are obtained by a plurality of different spectral intensity measuring methods with respect to the object to be measured, a magnetic resonance spectral intensity value at the predetermined position is obtained directly or indirectly from a measured results of the magnetic resonance spectral intensity values that is included in the magnetic resonance imaging image information and the predetermined position is set to be identical for all of the several varieties of magnetic resonance imaging image information with respect to each of the magnetic resonance imaging image information, and new image information at the predetermined position is derived by linear calculation between the spectral intensity values.

Method for processing magnetic resonance imaging image information and magnetic resonance imaging system

An antimicrobial drug having excellent antimicrobial activity and high safety is disclosed, which comprises as an active ingredient, a quinolone derivative having a substituted aminocycloalkylpyrrolidine as a substituent and which is further substituted with various substituents, represented by formula (I), its salts and hydrates thereof:

Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives

An antimicrobial drug having excellent antimicrobial activity and high safety is disclosed, which comprises as an active ingredient, a quinolone-derivative having a substituted aminocycloalkylpyrrolidine as a substituent and which is further substituted with various substituents, represented by formula (I), its salts and hydrates thereof: ##STR1## wherein Q is represented by formula (II) or (IV). ##STR2## Also disclosed is a quinolone derivative where R.sup.4 and the substituent on the pyrrolidine ring of the following formula: ##STR3## are located at the cis-configuration; and Q is represented by the formula: ##STR4##

Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted

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Tokyo, Japan

Satoru Miyauchi