Oncolys Biopharma, Inc.

Satoru Kyo

Noriaki Tanaka

Toshiyoshi Fujiwara

Hiroyuki Mizuguchi

Takao Hayakawa

Yoshiko Shirakiya

Takeshi Kawashima

By using a virus having a gene sequence comprising a telomerase promoter and an E1 gene (preferably a sequence comprising E1A gene, IRES sequence and E1B gene) or by using an anticancer agent comprising the virus, the virus replicates in cancer cells to thereby produce an efficient anticancer effect.

Oncolytic virus replicating selectively in tumor cells

The present invention provides a reagent for cancer cell detection or cancer diagnosis. The present invention relates to a reagent for cancer cell detection, comprising a recombinant virus where a replication cassette comprising a promoter from human telomerase, an E1A gene, an IRES sequence and an E1B gene in this order is integrated in E1 region of the viral genome and a labeling cassette comprising a gene encoding a labeling protein and a promoter capable of regulating the expression of the gene encoding the labeling protein is integrated in E3 region of the viral genome.

Telomelysin/GFP-expressing recombinant virus

Growing community of inventors

Ishikawa, Japan

Satoru Kyo