Kyorin Pharmaceutical Co., Ltd.

Satoru Katayama

Yasumichi Fukuda

Koji Murakami

Yoshikazu Asahina

Tomohiro Ide

Taku Shibue

Novel bicycloamide derivatives (general formula (1)) and pharmaceutically acceptable salts thereof effectively inhibit DPP-IV. The bicycloamide derivatives are represented by the general formula (1): Pharmaceutically acceptable salts thereof are also included (Example: (2S,4S)-1-[[(4-carbamoylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile)).

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Saitama, Japan

Satoru Katayama