Hitachi, Ltd.

Murata Manufacturing Co., Ltd.

Hitachi Microcomputer Engineering, Ltd.

The University of Tokyo

Murata Mfg. Co., Ltd.

Idac Theranostics, Inc.

Asahi Kasei Microdevices Corporation

Fujirebio Inc.

Tokyo University of Science Foundation

Hitachi Building Systems Co., Ltd.

Satoru Ito

Yuji Hara

Tatsuro Toya

Michihiro Murata

Norio Fukui

Keizou Yamamoto

Satoshi Awata

Satoru Kawabata

Yasuo Tada

Tetsujiro Sawao

Kouji Matsushima

Yoshiro Ishiwata

Shoji Yokochi

Satoshi Ueha

Kunihiro Tsubosaki

Gen Murakami

Satoshi Meguro

Kazuhiro Komori

Kiyoshi Nakamura

Masamichi Ishihara

Atsushi Hiraiwa

Setsuo Arita

Toshiyuki Sakuta

Toshimasa Kihara

Shigeru Takahashi

Kiichiro Mukai

Seiki Harada

Nao Saito

Satoru Inarida

Yoshiaki Uchida

Katsuhisa Usami

Masataka Ota

Yoshihiro Kurano

Shin-ichi Muramatsu

Seiichi Iwata

Harumi Wakimoto

Nobuhiro Ito

Katsuro Sugawara

Takeo Yoshimi

Yasuo Mori

Kazunori Ayabe

Yukio Sagawa

Isamu Wakamiya

Shyzi Sawada

Muneharu Nishio

Shigeyuki Shichino

Hiroyasu Aoki

Mikiya Suzuki

Takemitsu Ikeda

Koji Aoki

Disclosed is a means for reducing side effects of an immune checkpoint regulator that is used as an anticancer drug or the like. A side-effect reducing agent according to the present invention comprises as an effective ingredient an anti-CD4 antibody having a high cytotoxic activity, or an anti-CD4 antibody or antigen-binding fragment thereof which antibody or fragment comprises a cytotoxic component bound thereto. The anti-CD4 antibody is a human-type chimeric antibody, humanized antibody or human antibody against human CD4. The immune checkpoint regulator may be, for example, an anti-PD-L1 antibody, an antagonistic anti-CTLA-4 antibody, or an agonistic anti-OX40 antibody.

Method for reducing side effects of immune checkpoint control agent

Means that enables monitoring of an anticancer effect of an anti-CD4 antibody or an anticancer drug targeting an immune checkpoint is disclosed. The method for testing a therapeutic effect of a cancer therapy of the present invention is a method for testing a therapeutic effect of an anticancer drug comprising as an effective ingredient an anti-CD4 antibody or an anticancer drug targeting an immune checkpoint, which method comprises investigation of expression of (1) at least one immune checkpoint receptor, (2) CD8, and (3) at least one cell surface molecule selected from the group consisting of CD44 and CD45RO, on T cells using a sample derived from a patient who received the anticancer drug. Induction of a T cell population which is positive for the immune checkpoint molecule (1) and positive for CD8, and which shows high expression of CD44 and/or high expression of CD45RO, indicates that said anticancer drug is producing a therapeutic effect in said patient.

Method for assessing therapeutic effect of anti-cancer agent having anti-CD4 antibody as active ingredient

A DC-DC converter includes: an error amplifier for outputting an error between an output voltage and a predetermined voltage; a phase compensation impedance element for accumulating the error across one end to generate an error phase; a determination unit for determining whether the voltage output by the error amplifier is higher, or lower than a reference voltage that is consonant with the predetermined voltage, and outputting a determination signal indicating determination results; and a voltage setting unit for setting a voltage for one end of the phase compensation impedance element higher than a lower output voltage limit for the error amplifier when the determination signal indicates that the voltage output by the error amplifier is lower than the reference voltage, or for canceling setting of the voltage when the determination signal indicates that the voltage output by the error amplifier is higher than the reference voltage.

DC-DC converter

A communication system in trains comprises a control data communication deviceand an image data communication deviceinstalled in each of the cars. The control data communication devicetransmits train operation information, train location information, control instructions of train-mounted apparatuses, and the like. The image data communication devicetransmits image information such as moving images and still images, audio information such as in-train announcement, textual information for caption display, and operation log information of apparatuses, which form the contents, to a display unitinstalled in each of the cars and to apparatusessuch as a telephone. The display unitswitches the display on the screen in accordance with train control information transmitted from the control data communication devicethrough the image data communication device

Communication system in trains

An infrared sensor comprises: a stem; a pyroelectric element arranged on one side of the stem; a conversion circuit for changing electric charge generated in the pyroelectric element into a signal; and a plurality of lead terminals formed so as to be extended to the other side of the stem and electrically connected to the conversion circuit, the lead terminals being fixed to the stem by caulking.

Infrared sensor

A method for simply measuring a 1,2-dicarbonyl derivative in multiple specimens is provided, which comprises converting a 1,2-dicarbonyl derivative to a pyrazine derivative represented by the formula (I):

Antibody that recognizes pyrazine derivative and method for measuring 1,2-dicarbonyl derivative using said antibody

A pyroelectric infrared sensor device (10) with improved relative detectivity and with which it is easier to change the relative detectivity, and also with reduced manufacturing cost. This sensor device (10) includes a pyroelectric unit (12) having an alternating lamination of internal electrodes (16) and pyroelectric layers (14) with a predetermined thickness t. The ends of the internal electrodes (16) which extend perpendicular to the length direction thereof are respectively exposed at alternate terminal surfaces of the pyroelectric unit (12) and external electrodes (18) are connected to the terminal ends of those internal electrodes (16), respectively. The pyroelectric infrared sensor device (10) is horizontally polarized between the internal electrodes (16) via the external electrodes (18) with respect to the infrared light receiving plane thereof. The ends of the internal electrodes (16) perpendicular to the width direction thereof are exposed at the top and bottom surfaces of the pyroelectric unit (12) in such a manner that its top surface side will act as the light receiving plane of the pyroelectric infrared sensor device (10).

Infrared radiation sensitive device

A pyroelectric infrared sensor device with improved sensitivity and relative detection rate and reduced manufacturing cost. The infrared sensor device includes a substrate of rectangular shape. The substrate is made of a pyroelectric material, such as tetragonal-system lead titanate pyroelectric ceramics. A pair of comb-shaped electrode patterns each having a set of parallel conductive open-ended fingers are disposed on the top surface of the substrate such that the open-ended fingers of one electrode pattern are spatially interdigitated in relation to those of the other. The paired comb-shaped electrodes have at least three finger pairs whereas the interelectrode distance corresponding to the gap between neighboring fingers is greater than 100 micrometers. These comb-shaped electrodes satisfying the criteria render the pyroelectric material, upon application of a DC voltage between them, substantially horizontally polarizable at or near the top substrate surface which acts as the infrared light receiving plane. An opposite electrode is on the entire bottom surface of the substrate. This electrode has portions insulatively overlapping the comb-shaped electrodes with the pyroelectric material being sandwiched therebetween.

Pyroelectric infrared sensor device

A power conversion apparatus has a PWM power converter coupled to an A.C. power supply on one side and to a D.C. load on the other side, a voltage controller for adjusting the D.C. output voltage from the converter, a power factor controller for adjusting the power factor on the A.C. side of the converter, a command generator for generating a PWM modulation factor and a phase signal in response to the voltage and an output from the power factor controller, and a PWM modulation unit for controlling the converter in response to these command signals. The power factor controller is controlled to reduce its power factor when a control parameter relating to the modulation factor of the converter approaches its limit value, and the power of the D.C. load is limited when a control parameter relating to the input power of the converter approaches its limit value, such that the power factor of the power converter is allowed to be reduced and the power of the D.C. load is limited respectively in each designated region, thereby preventing any overcurrent even if the power supply voltage fluctuates. As a result, continuous operation is maintained, making it possible to reduce the capacity of the converter required for generating the same output power over the conventional converter.

Power conversion apparatus

A resin molded type semiconductor device has a metallic guard ring that is formed to cover the peripheral edge of the surface of a tetragonal semiconductor substrate. In order to prevent a passivation film on the guard ring from being cracked by stresses due to a resin mold package concentrating in the four corners of the semiconductor substrate, slits or rows of small holes are formed in the corner portions of the guard ring.

Resin molded type-semiconductor device having a conductor film

Resin molded type semiconductor device having a conductor film

A pyroelectric IR-sensor in which a pyroelectric light receiving element is mounted on a MID substrate or a ceramic substrate having a thermal conductivity less than 0.02 cal/cm.sec..degree.C. Both ends of the pyroelectric light receiving element are supported by the substrate, with the central portion of the pyroelectric light receiving element being spaced from the substrate. Chip parts are mounted on the substrate.

Pyroelectric IR-sensor

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Tokyo, Japan

Satoru Ito