Pfizer Corporation

Taiho Pharmaceutical Company Limited

Satoru Iguchi

Chikara Uchida

Tadashi Shimamura

Isao Miyazaki

Hidenori Fujita

Masanori Kato

Hiroki Sone

Koji Ando

Toyoharu Numata

Yoshinori Murata

Noriaki Murase

Yasuhiro Katsu

Tatsuo Ueki

Takahiro Asai

Tatsuya Yamagishi

Kazunari Nakao

Hirohide Noguchi

Takeshi Sagara

Masayuki Nakamura

Misato Hirano

Kana Kon-I

Fumihito Hosoi

Kei Oguchi

Takashi Kojima

Provided are a novel pyrimidine compound that inhibits HER2 activity and exhibits brain penetration properties, or a salt thereof, and a pharmaceutical composition comprising the same. A compound represented by the following formula (I), or a salt thereof: 

Substituted pyrrolo[2,3-d]pyrimidines as HER2 inhibitors

The problem to be solved by the present invention is to provide a novel compound having RET inhibitory activity. The present invention also provides a pharmaceutical preparation that is useful for the prevention and/or treatment of RET-related diseases, particularly cancer, based on RET inhibitory activity. The present invention provides a compound represented by Formula (I): wherein A, R, and X are as defined in the specification; or a salt thereof.

Fused pyrimidine compound or salt thereof

Provided is a novel compound having BTK inhibitory action and a cell proliferation suppressing effect. Also provided is a medicine useful for the prevention and/or treatment of a disease associated with BTK, particularly cancer, based on BTK inhibitory action. A compound represented by formula (I) [wherein Rto R, W, A, Y and Z respectively have the meanings as defined in the specification], or a salt thereof is disclosed. 

This invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds for the manufacture of medicament for gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes and apnea syndrome. These compounds have 5-HTreceptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.

Benzimidazolone compounds having 5-HT4 receptor agonistic activity

This invention relates to compounds of the formula (I): wherein R, R, R, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HTreceptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.

Benzimidazolone carboxylic acid derivatives

This invention provides a compound of the formula (I):or a pharmaceutically acceptable salt thereof, wherein These compounds have 5-HTreceptor binding activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans. This invention also provides a pharmaceutical composition comprising the above compound.

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This invention provides a compound of the formula (I):wherein: These compounds are useful for the treatment of medical conditions mediated by prostaglamndin such as pain, fever or inflammation, etc. This invention also provides a pharmaceutical composition comprising the above compound.

Imidazole compounds as anti-inflammatory and analgesic agents

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Chita-gun, Japan

Satoru Iguchi