Kureha Kagaku Kogyo Kabushiki Kaisha

Satoru Enomotol

Kiro Asano

Hiromitsu Tanaka

Humio Tamura

A process for producing a steroid hormone-antitumor derivative which selectively affects to tumor or cancer cells comprises reacting X group of a steroid hormone derivative having the formula ##STR1## wherein ST represents a steroid moiety having a cyclophenanthrene hydrocarbon skeleton of gonane, estrane or androstane which is bound to carboxyl group by esterifying OH group on D ring with carboxyl group; and R' represents a C.sub.1 -C.sub.4 alkylene group and X represents a halogen atom, amino group, hydroxyl group, carboxyl group or a salt thereof, with a modified or non-modified reactive group of an antitumor drug to form a binded group of --O--, --COO--, --CONH--, --NH-- or ##STR2##

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Fujisawa, Japan

Satoru Enomotol