Kureha Kagaku Kogyo Kabushiki Kaisha

Kureha Chemical Industry Company, Limited

Satoru Enomoto

Yutaka Mukaida

Hitoshi Takita

Mikiro Yanaka

Hisayuki Wada

Kiro Asano

Hiromitsu Tanaka

Sadao Nishita

Humio Tamura

Chikao Yoshikumi

Minoru Ohara

Saburo Ueno

Tetsuya Hotta

Tsuyoshi Saito

Toshihiko Wada

Azuma Okubo

Akiyoshi Nakajima

Disclosed is a method for producing the high-quality mycelia of the Basidiomycetes from culture thereof by promoting growth of the fungus as well as differentiation of the cells and attendant organization thereof by adding to the culture medium a straight chain saturated aliphatic alcohol with a catbon number within a specified range of 26 to 36 carbon atoms.

Growth promoting method for basidiomycetes

A process for producing a steroid hormone-antitumor derivative which selectively affects to tumor or cancer cells comprises reacting X group of a steroid hormone derivative having the formula ##STR1## wherein ST represents a steroid moiety having a cyclophenanthrene hydrocarbon skeleton of gonane, estrane or androstane which is bound to carboxyl group by esterifying OH group on D ring with carboxyl group; and R' represents a C.sub.1 -C.sub.4 alkylene group and X represents a halogen atom, amino group, hydroxyl group, carboxyl group or a salt thereof, with a modified or non-modified reactive group of an antitumor drug to form a binded group of ##STR2##

Steroid hormone-antitumor derivatives

The Chlorambucil derivatives are novel compounds having the formula (I). ##STR1## wherein R represents a hydrogen atom or an acyl group such as ##STR2## and n is 1 or 2. The Chlorambucil derivatives can be produced by binding Chlorambucil to hydroxyl group at 17-position of estradiol or its derivative in the presence of a binding agent selected from the group consisting of compounds having the formula

Chlorambucil derivatives

Methylated prostaglandine derivatives are steroids derivatives having at 17 position, methylated prostaglandine group such as

Methylated prostaglandin derivatives

Conjugates of amino sugar-steroid hormone are prepared by binding an amino sugar to steroid hormone at 3- or 17-position by a direct reaction or by binding with a binding agent, and the conjugate is useful in an enzyme immunoassay method.

Conjugate of amino sugar-steroid hormone

Disclosed herein is a process for preparing a normal long chain alkanoic acid having 26 to 36 carbon atoms, in which a trihalogenomethane is added to a normal alpha-olefin having 25 to 35 carbon atoms in the presence of a radical initiator and then the thus formed 1,1,1-trihalogenoalkane is hydrolyzed with an alkali to convert into the normal long chain alkanoic acid.

Process for preparing a normal long chain alkanoic acid

Disclosed in this invention are protein-bound polysaccharides having antitumor activities. The polysaccharides have molecular weight within a specified range and present a pattern of color reaction peculiar to the saccharides as well as a pattern of color reaction characteristic of amino acids and peptide bonds. The proton nuclear magnetic resonance spectra of the polysaccharides show peculiar absorption bands. The ratio of the polysaccharide portion to protein portion in the polysaccharides is within a specified range. The protein-bound polysaccharides can be obtained by extraction of the mycelia and/or fruit bodies of fungi belonging to Coriolus of Polyporaceae of Basidiomycetes.

Protein-bound polysaccharides

The palladium complex disclosed herein is bis[tri(ortho-tolyl)phosphine] :palladium which is produced by reacting a palladium salt with tri(ortho-tolyl)phosphine and reducing the resultant bis[tri(ortho-tolyl)phosphine] palladium salt with an alcoholic alkali. This complex is useful as a catalyst for the production of 1,3-diene oligomers.

Palladium complex, process for the preparation thereof and catalyst for

Process for the preparation of Chlorambucil derivatives

Extraction of a fungus of the class Basidiomycetes belonging to the Coriolus genus with an aqueous solvent under pressure and at a temperature of 120.degree. C. to 200.degree. C. gives an anti-transplanted sarcoma 180 tumorigenic substance in a high yield.

Process for the preparation of anti-transplanted sarcoma 180 tumorigenic

Prostaglandine derivatives are composed of a prostaglandine and a steriod hormone with or without a binding group. The prostaglandine derivatives have extraordinarily reduced side-effect and superior physiological activity, particularly effect of abortion in comparison with those of prostaglandines.

Prostaglandine derivatives

The palladium complex disclosed herein is bis[tri(orthotolyl)phosphine] palladium which is produced by reacting a palladium salt with tri(ortho-tolyl)phosphine and reducing the resultant bis[tri(ortho-tolyl)phosphine] palladium salt with an alcoholic alkali. This complex is useful as a catalyst for the production of 1,3-diene oligomers.

Palladium complex

An air drying high solid coating composition containing 90% or more of solid components and consisting of (1) 95 - 50 parts by weight of low viscosity alkyd resin having an oil length of 60 or higher and a viscosity of Z.sub.4 or lower, (II) 5 - 50 parts by weight of 1,1-bis-(1'-methyl-2'-vinyl-4',6'-heptadienoxy)-alkane, and if necessary, (III) other components such as pigments, organic solvents and additives. The coating composition is quite effective in the prevention of air pollution and the saving of resources.

Air drying high solid coating composition

A composition including a diisocyanate and 1-methyl-2-vinyl-4,6-heptadienol. This composition is capable of curing in air at room temperature after aging in a dry nitrogen atmosphere.

Growing community of inventors

Fujisawa, Japan

Satoru Enomoto