Kyoto Pharmaceutical Industries, Ltd.

Satoru Azukizawa

Hiroaki Shirahase

Hiroshi Matsui

Masayasu Kasai

Akihisa Yoshimi

Hideo Kobayashi

The novel heterocyclic compound of the present invention is a novel heterocyclic compound having the formula (I) Y: R&#x2014;C(R)&#x2550;N&#x2014;O&#x2014;wherein Ris H or Calkyl, Ris H, &#x2014;CO&#x2014;C(R)&#x2550;C(R)&#x2014;Rwherein Ris H or Calkyl, and Ris Calkyl, Calkenyl and the like, and the like, Y is the following group wherein X is O or S, Ris the same as R, Ris R&#x2014;C(R)&#x2550;C(R)&#x2014; wherein Ris the same as R, Ris Calkyl and the like, and the like, Ris the same as R, and Ris aryl and the like, Y&#x2014;(CH)n-O&#x2014; is bonded to the 6- or 7-position of the tetrahydroisoquinoline skeleton, and n is an integer of 1 to 4, or a pharmaceutically acceptable salt thereof. The compound (I) of the present invention is useful as a hypoglycemic agent, a hypolipidemic agent, an insulin resistance improver, a therapeutic agent of diabetes, a therapeutic agent of diabetic complications, a glucose tolerance improver, an anti-arteriosclerosis agent, an anti-obesity agent, an antiinflammatory agent, an agent for the prophylaxis or treatment of PPAR-mediated diseases or an agent for the prophylaxis or treatment of syndrome X.

Heterocyclic compound and medicinal use thereof

The novel heterocyclic derivative of the present invention is a novel heterocyclic derivative having the formula (I')wherein Ris a hydrogen atom or Calkyl, Ris &#x2014;CO&#x2014;C(R)&#x2550;C(R)&#x2014;Rwherein Ris a hydrogen atom or Calkyl, and Ris Calkyl, Calkenyl, aryl or aromatic heterocycle, &#x2014;CO&#x2014;C&#x2261;C&#x2014;Rwherein Ris Calkyl and the like, Ris a hydrogen atom or Calkyl, X is an oxygen atom or a sulfur atom, Ris optionally substituted phenyl, and n is an integer of 1 to 4, or a pharmaceutically acceptable salt thereof. The compound (I&#x2032;) of the present invention is useful as a hypoglycemic agent, a hypolipidemic agent, an insulin resistance improver, a therapeutic agent of diabetes, a therapeutic agent of diabetic complications, a glucose tolerance improver, an anti-arteriosclerosis agent, an anti-obesity agent, an antiinflammatory agent, an agent for the prophylaxis or treatment of PPAR-mediated diseases and an agent for the prophylaxis or treatment of syndrome X.

Heterocyclic derivatives and medicinal use thereof

Heterocyclic compounds and salts thereof and medicinal use of the same

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Kyoto, Japan

Satoru Azukizawa