Itoham Foods Inc.

Senju Pharmaceutical Co., Ltd.

Satomi Onoue

Yukuo Yoshida

Kazuhisa Kashimoto

Asami Matsumoto

Yoko Minagawa

Atsuko Fujii

Kousuke Endo

Remedies for dry eye and diseases associated with dry eye which contain as the active ingredient peptides represented by the general formula (I):H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-X-Gln-X-Ala-Val-X-X-Tyr-Leu-X-X(SEQ ID NOS: 26-36) &#x2003;&#x2003;(I)wherein X, Xand Xrepresent Lys or Arg, respectively; Xrepresents Met, Leu or nLeu; Xrepresents a chemical bond, Asn, Asn-Ser, Asn-Ser-Ile, Asn-Ser-Ile-Leu(SEQ ID NO: 37) or Asn-Ser-Ile-Leu-Asn-X(SEQ ID NOS: 38-43) (wherein Xrepresents a chemical bond, Gly, etc.); and Xrepresents &#x2014;OH or &#x2014;NH, or pharmaceutically acceptable salts thereof:.

Remedies for dry eye and diseases associated with dry eye

This invention provides a pharmaceutical composition comprising, as an active ingredient, a peptide derived from a PACAP or VIP peptide or a pharmaceutically acceptable salt thereof. This invention provides a PACAP/VIP derivative that can inhibit tautomerization in a solution and that can be applied to clinical applications over a long period of time. Such peptides are useful for ameliorating symptoms of diseases, such as regressive neurodegenerative diseases, erectile dysfunction, and bronchial asthma.

Peptides and medicinal compositions containing the same

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Moriya, Japan

Satomi Onoue