Wockhardt Limited

The Company of Wockhardt Limited

Satish Bhavsar

Mahesh Vithalbhai Patel

Prasad Keshav Deshpande

Ravindra Dattatraya Yeole

Amit Chandra Mishra

Bharat Kalidas Trivedi

Sachin Subhash Bhagwat

Ravikumar Tadiparthi

Noel John De Souza

Yati Chugh

Shivaji Sampatrao Pawar

Sunil Gupta

Mohammad Alam Jafri

Deepak Dekhane

Vikas Vitthalrao Deshmukh

Karuna Suresh Wankhede

Santosh Diwakar

Kiran Ramchandra Patil

Vijay Prakash Chavan

Vijay Patil

Manish Solanki

Dattatraya Vitthal Wani

Ravindra Dattatrya Yeole

Vikas Vithalrao Deshmukh

Bharat Trivedi

Sodium salt of (2S,5R)-6-benzyloxy-7-oxo-1,6-diaza-bicyclo[3.2.1]octane-2-carboxylic acid and a process for its preparation is disclosed.

Sodium salt of (2S, 5R)-6-benzyloxy-7-oxo-1,6-diaza-bicyclo [3.2.1] octane-2-carboxylic acid and its preparation

A process for preparation of a compound of Formula (I) is disclosed. 

Process for preparation of sodium (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylate

The invention relates to ketolide compounds of Formula (I) and their pharmaceutically acceptable salts, solvates, hydrates, polymorphs and stereoisomers having antimicrobial activity. The invention also provides pharmaceutical compositions containing the compounds of invention and methods of treating or preventing microbial infections with the compounds of invention, wherein, T is &#x2014;C*H(R)&#x2014;P-Q; Ris hydrogen; unsubstituted or substituted lower alkyl, cycloalkyl or aryl; P is heteroaryl ring; Q is unsubstituted or substituted aryl or heteroaryl ring; and P is attached to Q via carbon-carbon link; and Ris hydrogen or fluorine, With the provision that when Ris hydrogen, Ris fluorine. 

Ketolide compounds

A polymorphic forms of the hydrochloride salt and mesylate salt of racemic (&#xb1;)-1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid, dextrorotatory R-(+)-1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid and S-(&#x2212;)-1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid having formula (I) and (II) respectively are described. Processes for their preparation are also described. The invention further relates to methods of using, and pharmaceutical compositions comprising the compounds of the invention for treatment of bacterial infections in mammals.

Polymorphs of racemic, dextrorotatory, and levorotatory enantioners of 1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid hydrochloride and mesylate salts

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Aurangabad, India

Satish Bhavsar