Council of Scientific and Industrial Research

Sateesh Madhi

Boyapati Manoranjan Choudary

Naidu Sreenivasa Chowdari

Lakshmi Kantam Mannepalli

Mannepalli Lakshmi Kantam

Jyothi Karangula

The present invention comprises a simplified synthesis of (+)-diltiazem through IE-PdOsW wherein IE is ion-exchanger, catalyzed three-component coupling reaction and Fe-exchanged clay catalyzed ring opening of sulfite with 2-aminothiophenol followed by cyclization as key steps.

Process for preparing diltiazem using a heterogeneous trifunctional catalyst

The present invention relates to a multifunctional reusable catalyst and to a process for the preparation thereof on a single matrix of the support to perform multicomponent reaction in a single pot. The multifunctional catalysts of the invention are useful for the synthesis of chiral vicinal diols by tandem and/or simultaneous reactions involving Heck coupling, N-oxidation and AD reaction of olefins in presence of cinchona alkaloid compounds both as an native one and immobilized one in the said matrix support. This invention also relates to a process for preparing vicinal diols by asymmetric dihydroxylation of olefins in presence of cinchona alkaloid compounds employing reusable multifunctional catalysts as heterogeneous catalysts in place of soluble osmium catalysts.

MULTIFUNCTIONAL CATALYST USEFUL IN THE SYNTHESIS OF CHIRAL VICINAL DIOLS AND PROCESS FOR THE PREPARATION THEREOF, AND PROCESS FOR THE PREPARATION OF CHIRAL VICINAL DIOLS USING SAID MULTIFUNCTIONAL CATALYSTS

The present invention relates to an improved process for the preparation of taxol side chain by synthesizing (2R,3S)-2,3-dihydroxy-3-phenylpropionate with greater than 99% enantioselectivity and devoid of osmium even in crude form in a single pot using a recyclable multifunctional catalysts, conversion of diol obtained without further crystallization into bromoacetate, reaction of bromoacetate with NaN in organic solvent followed by deacetylation with to obtain azido alcohol, benzoylation followed by hydrogenation of azido alcohol to obtain the (2R,3S)-(N-)-benzoyl-3-phenylisoserine methyl ester in 67% yield.

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Andhra Pradesh, India

Sateesh Madhi