G.d. Searle & Company

Pharmacia Corporation

Pharmacia Corporation (of Pfizer, Inc.)

Sastry A Kunda

Leo J Letendre

Jon P Lawson

Dennis K Anderson

John S Ng

Bernhard Erb

Yuen-Lung L Sing

Joseph J Wieczorek

Mark John Pozzo

Edward E Yonan

Chin Liu

Ping T Wang

Julio A Baez

Gennaro Mucciariello

Fortunato Vanzanella

Richard M Weier

Thomas R Kowar

Shaun Raj Selness

Gopichand Yalamanchili

Michael Mao

Win Naing

John Walker

Jerry D Clark

Lisa L McDermott

Patrick H Lau

Christine B Seymour

Gary A De Crescenzo

Jodi L Moe

Partha Mudipalli

Tobin C Schilke

Shekhar Viswanath

Kimberley C Allen

John E Baldus

Todd Boehlow

Dan R Dukesherer

Albert D Edney

Tom Fevig

Multiple novel keto-substituted intermediates are provided for the synthesis of epoxymexrenone, useful as an Aldosterone Receptor Antagonist.

Keto-substituted steroid compounds

Intermediates in the preparation of 9,11-epoxy steroids are disclosed. Particularly, disclosed are 11,12-epoxy steroid, 4,5-9,11-diepoxy steroid and 12-keto steroid intermediates.

Processes for preparation of 9,11-epoxy steroids and intermediates useful therein

This invention is directed generally to a process for making substituted pyrazoles, tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers. The substituted pyrazoles correspond in structure to Formula (I): wherein R, R, R, Y, Y, Y, Y, and Yare as defined in the specification.

Process for making substituted pyrazoles

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein:

Process for preparation of 9, 11-epoxy steroids and intermediates useful therein

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein: &#x2014;A&#x2014;A&#x2014;, &#x2014;B&#x2014;B&#x2014;, R, R, Rand Rare as defined in the specification.

Processes for the preparation of 4,5-dihydro-5,7-lactone steroid compounds are provided.

Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein

Process for preparation of 9,11-epoxy steroids and intermediates useful therein

5&bgr;-cyano-substituted steroid compounds

A process for the formation of an epoxy compound comprising contacting a substrate compound having an olefinic double bond with a peroxide compound in the presence of a peroxide activator, said peroxide activator corresponding to the formula:

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone, useful as a diuretic, and other compounds of Formula I

Keto-Substituted Steroid Compounds

Multiple reaction schemes, process steps and intermediates are provided for the synthesis of epoxymexrenone, useful as a diuretic, and other compounds of Formula I

A process for preparing a benzo fused heterocyclic sulfonyl halide comprising reacting a benzo fused heterocyclic compound with an SO.sub.3 complex in the presence of a water immiscible, non-reactive solvent, at a temperature of from about 0.degree. C. to about 75.degree. C., cooling, if necessary, to a temperature of from about -25.degree. C. to about 65.degree. C. and then adding oxalyl halide.

Synthesis of benzo fused heterocyclic sulfonyl chlorides

Multiple reaction schemes, process steps and intermediates are provided for the synthesis of epoxymexrenone, useful as a diuretic, and other 9,11-epoxy-steroids.

Processes for preparation of 9,11-epoxy steroids and intermediates

Growing community of inventors

Chesterfield, MO, United States of America

Sastry A Kunda