Merck Sharp + Dohme Corp.

Saso Cemerski

Jared N Cumming

Benjamin Wesley Trotter

Johnny E Kopinja

Samanthi A Perera

Archie Ngai-Chiu Tse

Therapeutic combinations that comprise at least one antagonist of the Programmed Death 1 receptor (PD-1) and at least one benzo[b]thiophene compound that activates the Stimulator of Interferon Genes (STING) pathway are disclosed herein. Also disclosed is the use of such therapeutic combinations for the treatment of cancers.

Combinations of PD-1 antagonists and benzo [b] thiophene STING agonists for cancer treatment

Therapies comprising administering at least one benzo[b]thiophene compound that activates the Stimulator of Interferon Genes (STING) pathway, and the use of such therapies in the treatment of cell-proliferation disorders such as cancer, are disclosed herein.

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Norfolk, MA, United States of America

Saso Cemerski