Universitéde Montreal

Bristol-myers Squibb Compnay

UniversitÈ Laval

Gemin X Pharmaceuticals Canada Inc.

Angiochem Inc.

Gemin X Biotechnologies Inc.

Sasmita Tripathy

Giorgio Attardo

Jean-Francois Lavallee

Edward H Ruediger

Wu Yang

Eldon Scott Priestley

Rejean Ruel

Jeremy M Richter

Terrence W Doyle

Pierre Louis Beaulieu

Xiaojun Zhang

Oz Scott Halpern

Wen Jiang

Samuel Kaye Reznik

Martin Gagnon

Jacques Banville

Michel Demeule

Samuel C Fortin

Elise Rioux

James B McAlpine

Yannick Rose

Gaoqiang Yang

Michael Dore

Xavier Billot

Angela M Stafford

Alain Larocque

Joanne Tan

Pierre Beauparlant

Jean-Christophe Currie

Mukund Ghavre

Hugo Lavoie

Eric Beaulieu

Doris Schuetz

Emeline Benoit

Elisc Rioux

Rosa Ubillas

Zhiying Zhang

Terrance W Deyle

Kenza Dairi

Compounds, compositions and their use in the treatment of a proliferative disease or condition such as a said proliferative disease or disorder is associated with a RAF gene mutation and/or a RAS gene mutation. The compounds disclosed are of Formula I or a pharmaceutically acceptable salt or solvate thereof, wherein R, R, R, X, X, Xand Xare as defined herein:

Pyrido[3,2-d]pyrimidine compounds uses thereof for treating a proliferative disease

The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

Biarylmethyl heterocycles

The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or &#x3b2;-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

The invention relates to dendrimers conjugated to multiple targeting peptides and one or more therapeutic, diagnostic, or imaging agents for delivery of such agents across the blood-brain barrier and into certain cell types including, cells expressing the LRP-1 receptor. Also described are methods of making compounds that comprise dendrimers conjugated to targeting peptides and therapeutic, diagnostic, or imaging agents.

Peptide-dendrimer conjugates and uses thereof

The present invention features compounds having the Formula (Ia) and (Ib) (e.g., a compound of any of Formulas ((Ia-2)-(Ia-21)), including other tautomers, stereoisomers, E/Z stereoisomers, prodrugs, pharmaceutically acceptable salts, and compositions thereof. The invention also features methods for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient by administering an effective amount of a compound of Formula (Ia) or (Ib). The invention also features a method for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient that includes administering to a patient in need thereof an effective amount of a compound of Formula (IIa) or (IIb) (e.g., a compound of any of Formulas ((IIa-2)-(IIa-6)). The compounds described herein (e.g., a compound of Formulas (Ia), (Ib), (IIa), or (IIb)) can also be used as anticonvulsants.

Pyrimidines as novel therapeutic agents

The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.

Triheterocyclic compounds and compositions thereof

Methods for treating cancer

The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, or for inducing apoptosis in a cancer or neoplastic cell. The compounds, compositions, and methods of the invention are further useful for treating or preventing a fungal infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a fungus.

Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents

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Pierrefonds, Canada

Sasmita Tripathy