Gruenenthal Gmbh

Grunenthal Gmbh

Gruenthal Gmbh

Saskia Zemolka

Werner Guenter Englberger

Klaus Linz

Stefan Schunk

Hans Schick

Wolfgang Schröder

Helmut Sonnenschein

Klaus Schiene

Michael Haurand

Bert Nolte

Fritz Theil

Derek John Saunders

Claudia Hinze

Sven Kuehnert

Heinz Graubaum

Sven Frormann

Babette-Yvonne Kögel

Gregor Bahrenberg

Thomas Christoph

Stefan Oberboersch

Ruth Jostock

Melanie Reich

Corinna Sundermann

Robert Frank

Beatrix Merla

Sven Kühnert

Michael Gruss

Wolfgang Schroeder

Birgitta Henkel

Dagmar Kaulartz

József Bálint

Thomas Tzschentke

Stefan Oberbörsch

Jens Kaufmann

Birgit Roloff

Ellen Bergrath

Julian Gebauer

Wolfgang Schröber

Spirocyclic cyclohexane compounds corresponding to formula I In which R, R, Rand Rthrough Rand X have defined meanings, a process for their preparation, pharmaceutical compositions containing such compounds, and the use of such spirocyclic cyclohexane compounds in the treatment and/or inhibition of pain and other conditions mediated by the ORL-1 or the &#x3bc;-opioid receptor.

Spirocyclic cyclohexane compounds

The invention relates to substituted azaindole derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted azaindole derivatives for producing medicaments.

Spirocyclic azaindole derivatives

The invention relates to compounds that have an affinity to the &#x3bc;-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain or other conditions.

Substituted cyclohexyldiamines

The invention relates to compounds that have an affinity to the &#x3bc;-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.

Substituted spirocyclic cyclohexane derivatives

The invention relates to compounds which have an affinity for the &#x3bc; opioid receptor and the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.

Hydroxymethylcyclohexylamines

Spiro(5.5)undecane derivatives

The invention relates to substituted heteroaryl derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted heteroaryl derivatives for producing medicaments.

Substituted heteroaryl derivatives

The present invention relates to substituted propiolic acid amides, methods for the production thereof, medicaments containing these compounds and the use thereof for producing medicaments.

Substituted propiolic acid amides and their use for producing drugs

(Hetero)aryl cyclohexane derivatives

Substituted imidazo[2,1-b]thiazole compounds corresponding to formula I, a method for producing them, pharmaceutical compositions containing them, and the use thereof for regularing mGluR5 receptors, or for treating or inhibiting disorders or disease states at least partially mediated by mGluR5 receptor such as pain, anxiety attacks, drug or alcohol dependency, and others.

Substituted imidazo[2,1-b]thiazole compounds and uses thereof

Substituted benzo[d]isoxazol-3-yl amine compounds corresponding to formula I which exhibit an strong affinity to the KCNQ2/3 Kchannel, and which are suitable for treating or inhibiting pain and/or disorders or disease states that are at least partly mediated by the KCNQ2/3 Kchannel.

Substituted benzo[d]isoxazol-3-yl amine compounds as analgesics

Substituted bicyclic imidazo-3-yl-amine compounds are provided, as well as processes for the production thereof and pharmaceutical formulations containing these compounds. The use of these compounds for the production of pharmaceutical formulations and related methods of treatment are also provided.

Substituted bicyclic imidazo-3-ylamine compounds

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Aachen, Germany

Saskia Zemolka