Cytiva Sweden Ab

Ge Healthcare Bio-sciences Ab

Sasi Kumar Nutalapati

Klaus Gebauer

Ajit S Vernekar

Nachiket Karmarkar

Amit Kumar Sharma

Fredrik Oskar Lundstrom

Prashanth Hosabettu Mohan

Amit Kumar Singh

Mats Olsson

Karl Axel Jakob Liderfelt

Supti Datta

Jean Pierre Neff

Nityananda Maiya

Sameera Simha Hindupur

Karl Liderfelt

Rajan Thiyaga

Jakob Liderfelt

Narendra G R

Sasikumar Arumugam

Sangeetha Raghu Ramachandran

Sudheer Mygapula

Bashkar Hv

Shashidhar Hedge

Thiyaga Rajan

The invention discloses a method of controlling a transmembrane pressure (TMP) in a crossflow filtration apparatus, comprising the steps of: a) providing a crossflow filtration apparatus comprising a pump () fluidically connected via a retentate compartment () of a crossflow filter () and a length of flexible tubing to a regulator valve (1; 101) acting on the flexible tubing, wherein the regulator valve is a high precision pinch valve. The apparatus further comprises a first pressure transducer () adapted to measure a pressure between the retentate compartment and the regulator valve, a second pressure transducer () adapted to measure a pressure between the pump and the retentate compartment and a third pressure transducer () adapted to measure a pressure at a permeate outlet () of the crossflow filter, and a control unit () electrically or electromagnetically connected to said regulator valve, the first, second and third pressure transducers and optionally to the pump; b) pumping a liquid with the pump via the second pressure transducer, through the retentate compartment via the length of flexible tubing, the first pressure transducer and the regulator valve; c) controlling the regulator valve with the control unit, such that a TMP calculated by formula (I) TMP=(P+P)/2−Pcorresponds to a predetermined TMP value or to an interval between two predetermined TMP values, wherein Pis a pressure reading from the second pressure transducer, Pis a pressure reading from the first pressure transducer and Pis a pressure reading from the third pressure transducer.

Method for pressure control in crossflow filtration

The invention discloses a first unit () for treatment of a bioprocess liquid comprising a first lateral face (), a second lateral face () and a front face () which meets the two said lateral faces. The front face comprises: a plurality of valves () adapted to receive and act upon one or more legs () of a disposable flow path (); optionally one or more pumps () adapted to receive and act upon one or more legs of the disposable flow path; optionally one or more sensors () adapted to receive and to measure one or more parameters in one or more legs of the disposable flow path; wherein the plurality of valves and optional pumps and sensors are vertically offset from each other to give one or more legs of a disposable flow path received by said valves and optional pumps and sensors a slope of at least 3.0 degrees from the horizontal plane (h).

Unit for treatment of a bioprocess liquid

The disclosure generally relates to methods and apparatus for the efficient quantitative recovery of valuable biological fluids from filtration systems, more particularly to efficient quantitative recovery of valuable biological fluids from high precision separation systems suitable for use in the pharmaceutical and biotechnology industries.

Method for enhancing filtration yields in tangential flow filtration system

A method and a system for improving mixing of content in a containerprovided in a filter systemsaid method comprising providing a mixing loopparallel to a recirculation flow pathof the filter system

Mixing method and system

Filtration instrument

Growing community of inventors

Bengaluru, India

Sasi Kumar Nutalapati