Johns Hopkins University

Sashank Reddy

Hai-Quan Mao

Xiaowei Li

Justin Sacks

Russell E Martin

Russell Martin

Kevin Colbert

Gerald Brandacher

Xuesong Jiang

Kevin Feng

Brian Honewee Cho

Georgia C Yalanis

Ji Suk Choi

Calvin Chang

The presently disclosed composition and methods are provided for a nanofiber-hydrogel composite containing adipose cell binding moieties. A method for healing a soft tissue defect can include applying an adipose cell-binding composite material to a soft tissue defect in combination with exogenous adipose-derived cells or endogenous cells recruited from the surrounding tissue.

Mesenchymal cell-binding composite material for tissue restoration

A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

Nanofiber-hydrogel composites for cell and tissue delivery

Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration

A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.

Composite material for tissue restoration

The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.

Fiber-hydrogel composite surgical meshes for tissue repair

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Baltimore, MD, United States of America

Sashank Reddy