Rush University Medical Center

Sasha Shafikhani

Methods of administering apoptotic compensatory proliferation signaling vesicles (AC PS Vs), and pharmaceutical formulations thereof, are described herein. AC PS Vs can be used to promote proliferation of cells in injured or diseased tissues, for example by adding a therapeutically effective amount of APCSVs to the injured or diseased tissue.

Use of apoptotic compensatory proliferation signaling vesicles in tissue repair and wound healing

A method of treating a wound in a diabetic patient is provided. The method includes administering a therapeutically effective amount of Chemokine (C-C motif) ligand 2 (CCL2) to a wound site. In another aspect, a method of treating a wound in a diabetic patient is provided. The method includes assaying a level of CCL2 in the diabetic patient relative to a level of CCL2 in a normal subject and administering a therapeutically effective amount of CCL2 to the diabetic patient.

Methods of promotion of healing of diabetic wounds

The invention features a method of identifying a therapeutically active compound that inhibits apoptotic compensatory signaling complex (ACSC)-induced cell proliferation.

Growing community of inventors

Elmwood Park, IL, United States of America

Sasha Shafikhani