Technion Research & Development Foundation Limited

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Hadasit Medical Research Services and Development Ltd.

Sarit Sivan

Yechezkel Barenholz

Noah Lotan

Izhak Etsion

Avi Schroeder

Uri Dinnar

Dorit Nitzan

Grigory Halperin

Dorrit Nitzan

The present invention concerns methods of joint lubrication and/or prevention of cartilage wear making use of liposomes having membranes with at least one phospholipid (PL) of the group consisting of a glycerophospholipid (GPL) having two, being the same or different, C-Chydrocarbon chain and a sphingolipid (SPL) having a C-Chydrocarbon chain, the one or more membranes having a phase transition temperature in which solid ordered (SO) to liquid disordered (LD) phase transition occurs, the phase transition temperature being within a temperature of about 20&#xb0; C. to about 39&#xb0; C. for lubrication of joints.

Methods for joint lubrication and cartilage wear prevention making use of glycerophospholipids

Intravascular apparatus and method for locally treating a patient's blood vessel, are provided. The apparatus includes an implanted carrier ( ) for insertion into the vessel; and a biologically active agent ( ) immobilized to the carrier ( ), said biologically active agent ( ) reacting with a first substance to produce a second substance. The second substance is preferably a therapeutic agent, such as nitric oxide, for locally treating the vessel. The biologically active agent ( ) is preferably an enzyme such as nitrogen oxide synthase, and the first substance is preferably arginine introduced to the patient's body as part of a diet. According to another embodiment, the biologically active agent ( ) is a catalytic antibody and the first substance is a prodrug. Alternatively, the biologically active agent ( ) is a ribozyme. The method includes introducing into a patient's vessel an implantable carrier including a biologically active agent immobilized thereto, and reacting the biologically active agent with a first substance to locally produce a second substance.

Intravascular apparatus method

Growing community of inventors

Zichron Yaakov, Israel

Sarit Sivan