Columbia University

Epibone, Inc.

Sarindr Bhumiratana

Gordana Vunjak-Novakovic

Keith Yeager

Donald O Freytes

Warren L Grayson

Nina Tandon

George Eng

Robert Maidhof

Eric Jeffries

Melanie Horwitz

Qun Wan

Amandine Godier-Furnémont

Melanie Reschke

Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.

Engineering mechanically functional human cartilage and method of making same

A system for seeding therapeutic active ingredients (TAIs) onto a porous scaffold includes a first chamber for accommodating the scaffold, a TAI storage device for storing TAIs, at least one second chamber for storing TAI media, and a gas inlet for receiving gas from a compressed source. A flow circuit is coupled to the first chamber, the TAI storage device, the second chamber and the gas inlet for delivering the TAIs, the TAI media and the gas to the scaffold. A pump pumps at least one of the TAIs, the TAI media and the gas in the flow circuit. The system also includes a processor that regulates the delivery of the TAIs, the TAI media and the gas to the scaffold via a plurality of valves.

System and method for seeding and culturing

The present invention relates to a porous polymer material (or scaffold), and more particularly to a polymer-ceramic composite having interconnected pores and a porosity of about 50% to 90%. The scaffold is bioresorbable and exhibits advantageous mechanical properties that mimic those found in natural bone. Methods of preparing the scaffolds and using them in skeletal tissue engineering applications (e.g., as bone grafts to repair osteochondral defects and ligaments) is also described.

Porous polymer scaffold and preparation method thereof

A perfusion bioreactor chamber for engineering a broad spectrum of tissues. The bioreactor allows controlled distribution of fluid through or around scaffolding materials of various shapes, structures and topologies during prolonged periods of cultivation.

Perfusion bioreactor with tissue flow control and live imaging compatibility

Disclosed are bioreactor devices, systems and methods. A bioreactor system can include one or more bioreactor modules that can be individually controllable and identifiable. A bioreactor module can be connected to one or more functional modules such as a pump module, a stimulation signal generation module, a motor module, a mechanical transmission module, a gas exchange module, a temperature module, a humidity module and/or a COmodule, among others. The bioreactor and functional modules can include standard or universal connectors to facilitate connection and movement of modules. The bioreactor system can be controlled and/or monitored by a controller that can individually identify and control each connected module and that can be adapted to collect signal data from sensors embedded in any of the modules.

Bioreactor, devices, systems and methods

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Sarindr Bhumiratana