University of California

University of Colorado

The General Hospital Corporation

Sari Mahon

Matthew D Brenner

Gerry R Boss

Adriano Chan

Vikhyat Bebarta

Zhongping Chen

Randall T Peterson

Gerard Boss

Andrew Emon Heidari

Joseph Jing

Robert Gerszten

Anjali Nath

Matt Brenner

Calum MacRae

Provided is a method, and pharmaceutical composition, to treat or prevent cyanide poisoning and/or methylmercaptan poisoning comprising administering to a subject in need an effective amount of tetrathionate by intramuscular injection or by intranasal administration. Also provided is a method for detecting the presence of tetrathionate in a sample by reacting it with cyanide and measuring the resulting thiocyanate with ferric nitrate.

Tetrathionate for cyanide and methylmercaptan poisoning

Methods and compositions for treating cyanide, sulfide, or methane-thiol exposure in a subject. The compositions may include one or more cobinamide compounds, such as an amino-tetrazole-cobinamide and/or a di-(amino-tetrazole)-cobinamide.

Cobinamide compounds as a cyanide, sulfide, or methane-thiol antidote

The present application provides, inter alia, a compound of Formula (I): or a pharmaceutically acceptable salt thereof, and methods of use of the compound of Formula (I) for treatment and prevention of cyanide poisoning.

Antidotes to cyanide poisoning

The invention includes an improvement in a method of assessing a gemstone having at least one planar face with an internally reflecting surface including the steps of optically modifying the at least one planar face of the gemstone to return a sample beam from an internally reflecting plane corresponding to the at least one planar face to an optical coherence tomography (OCT) system; selectively directing the sample beam from an optical coherence tomography (OCT) system onto the gemstone; and generating an OCT image map of the gemstone to determine volume, gem carat weight and/or quality.

Method to characterize cut gemstones using optical coherence tomography

Growing community of inventors

Irvine, CA, United States of America

Sari Mahon