Novavax, Inc.

Sarathi Boddapati

Jing-Hui Tian

Gale Smith

Ye Liu

Michael J Massare

Gregory M Glenn

Erica Shane

Cynthia Oliver

Jason Wong

Anushree Herwadkar

Yen-Huei Lin

Gregory J Glenn

Gale E Smith

Louis Fries

Iksung Cho

Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.

Vaccine compositions having improved stability and immunogenicity

Disclosed herein are methods and nanoparticles suitable for use in reducing exacerbations in COPD patients. The methods and compositions advantageously reduce the incidence of hospitalization in COPD patients that occurs in response to environmental insults such as exposure to or infection by RSV. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.

Methods and compositions for treating respiratory disease

Disclosed herein are multivalent nanoparticle vaccine compositions suitable for use in influenza vaccines. The nanoparticles include effective amounts of influenza glycoproteins that provide increased immune responses compared to a commercially available influenza vaccine composition. The present disclosure also provides vaccine formulation strategies that are cost effective and are convenient for clinical use. Methods of administering the nanoparticle vaccine compositions to a subject are also disclosed.

Multivalent influenza nanoparticle vaccines

Growing community of inventors

Germantown, MD, United States of America

Sarathi Boddapati