The Rockefeller University

The Broad Institute, Inc.

Rensselaer Polytechnic Institute

Massachusetts General Hospital Corporation

University of California

The General Hospital Corporation

The Board Institute, Inc.

Sarah Stanley

Jeffrey M Friedman

Tomohiko Kawate

Deborah Hung

Motohisa Shimizu

Noriakie Iwase

Jonathan S Dordick

Jeremy Sauer

Daniel A Portnoy

Erik Van Dis

Chris Rae

Kimberly Sogi

Noriaki Iwase

The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.

Compositions and methods to modulate cell activity

A vaccine against() formulated for intranasal administration, comprises a first vaccine component comprising one or more() or() antigens, and a second vaccine component comprising a Stimulator of Interferon Genes (STING) activator.

Intranasal delivery of a cyclic-di-nucleotide adjuvanted vaccine for tuberculosis

The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.

Ferritin nanoparticle compositions and methods to modulate cell activity

The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof: 

Compounds for the treatment of mycobacterial infections

The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof:

Growing community of inventors

Berkeley, CA, United States of America

Sarah Stanley