California Institute of Technology

Basf Corporation

Sarah Reisman

Chen Xu

Kangway V Chuang

Roland Goetz

William M Clemons, Jr

Stephan Zuend

Martin John Mclaughlin

Kyoung-Soon Jang

Elliot P Farney

Roger Nani

Sean S Feng

Sergiy Levin

Michael Rombola

Carolyn L Ladd

This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R, R, R, R, R, R, R, R, Rand Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation Mwherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R, R, R, R, R, R, R, R, Z and Z′ have the meanings as defined in the description.

Process for the synthesis of non-racemic cyclohexenes

The present disclosure provides processes for preparing (+)-pleuromutilin and synthetic (+)-pleuromutilin produced therefrom. Also provided are intermediates prepared thereby and processes for preparing these intermediates.

Process for preparing pleuromutilin

This disclosure is related to methods for producing anhydroryanodol, ryanodol, or analogs thereof and novel compounds prepared thereby.

Synthetic route to anhydroryanodol, ryanodol and structural analogues

A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also provided.

Cysteine hydrazide nicotinamide for glycomics and glycoproteomics uses

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South Pasadena, CA, United States of America

Sarah Reisman