Akina, Inc.

Sk Joint Ventures Ii, LLC

Sarah Michelle Skidmore

Kinam Park

Yeonhee Yun

Byung Kook Lee

John Solomon Garner

John J Garner

Larry Fultz

Methods for the formulation of biodegradable microparticles for delivery of protein drugs, such astoxin, have been developed. The methods include the steps of precipitating and washing proteins with organic solvent to remove water prior to dispersing in polymer-dissolved organic solvent to prevent exposure to water/solvent interfaces and maintain bioactivity of the protein drugs and fabrication of microparticles by either template or emulsion method. Biodegradable microparticles, formed of one or more biodegradable polymers having entrapped in the polymer one or more protein agents, such astoxin, are also provided. Precipitatedtoxin andtoxin-loaded microparticles can also be formulated into thermogels or crosslinked hydrogels. The stability of the protein within these microparticles, as well as the controlled release of the entrapped agents, provides for sustained efficacy of the agents.

Biodegradable polymer formulations for extended efficacy of botulinum toxin

Methods for the formulation of biodegradable microparticles for delivery of protein drugs, such as botulinum toxin, have been developed. The methods include the steps of precipitating and washing proteins with organic solvent to remove water prior to dispersing in polymer-dissolved organic solvent to prevent exposure to water/solvent interfaces and maintain bioactivity of the protein drugs and fabrication of microparticles by either template or emulsion method. Biodegradable microparticles, formed of one or more biodegradable polymers having entrapped in the polymer one or more protein agents, such as botulinum toxin, are also provided. Precipitated botulinum toxin and botulinum toxin-loaded microparticles can also be formulated into thermogels or crosslinked hydrogels. The stability of the protein within these microparticles, as well as the controlled release of the entrapped agents, provides for sustained efficacy of the agents.

A semi-automated device that provides a mechanism to produce large-scale microparticle formulations of specific sizes with no scum layer formation, and a method for using the device.

Growing community of inventors

Lafayette, IN, United States of America

Sarah Michelle Skidmore