University of Massachusetts

Sarah L Perry

Shuo Sui

Kithmie Harshana Malagodapathiranage

Jessica Deborah Schiffman

Elvan Cavac

Yasaman Gholamalipour

Xiangxi Meng

Christos Dimitrios Dimitrakopoulos

Craig Martin

Craig T Martin

Shou Sui

Yuxi Wang

Described herein are synthetic methods for producing sequence-specific RNA oligonucleotides that eliminate impurities produced in prior art methods. In one aspect, an end-protected capture DNA complementary to a portion of the product RNA is employed. In another aspect, the template DNA is covalently or noncovalently linked to the RNA polymerase, either directly or through the use of a nontemplate DNA. In a third aspect, a flow chamber is employed. All of the methods can be used in combination.

Enzymatic methods to generate high yields of sequence specific RNA oligonucleotides with extreme precision

Enzymatic methods to generate high yields of sequence specific rna with extreme precision

The invention provides a novel microfluidic platform for use in electro-crystallization and electro-crystallography experiments. The manufacturing and use of graphene as X-ray compatible electrodes allows the application of electric fields on-chip, during X-ray analysis. The presence of such electric fields can be used to modulate the structure of protein (or other) molecules in crystalline (for X-ray diffraction) or solution form (for X-ray scattering). Additionally, the presence of an electric field can be used to extend the lifetime of fragile samples by expediting the removal of reactive secondary radiation damage species.

Graphene-based electro-microfluidic devices and methods for protein structural analysis

This invention provides microfluidic devices with graphene films as architectural materials and methods of fabrication and use thereof in X-ray analysis.

Microfluidic devices having top and bottom layers of graphene and a middle layer with a patterned cavity

The invention provides compositions and methods for ultra-stable coating or printing from aqueous complex coacervates.

Ultra-stable printing and coatings using aqueous complex coacervates, and compositions and methods thereof

The invention provides novel polymer nanofiber or microfiber mats or membranes and methods for their preparation via an aqueous, one-step polyelectrolyte complexation and electrospinning of complex coacervates.

Growing community of inventors

Belchertown, MA, United States of America

Sarah L Perry