University of California

Samsung Electronics Co., Ltd.

Sarah L Blair

Andrew C Kummel

William C Trogler

James J Wang

Natalie Mendez

Jian Yang

Erin C Ward

Alexander Liberman

Christopher Barback

Tony R Reid

Farah Hedjran

Hotaik Lee

Tsai W Sung

Vanessa Herrera

Tsai-Wen Sung

Ultrasound imaging is a non-invasive, non-radioactive, and low cost technology for diagnosis and identification of implantable medical devices in real time. Developing new ultrasound activated coatings is important to broaden the utility of in vivo marking by ultrasound imaging. Ultrasound responsive macro-phase segregated micro-composite thin films were developed to be coated on medical devices composed of multiple materials and with multiple shapes and varying surface area. The macro-phase segregated in films having silica micro-shells in polycyanoacrylate produces strong color Doppler signals with the use of a standard clinical ultrasound transducer. Electron microscopy showed a macro-phase separation during slow curing of the cyanoacrylate adhesive, as air-filled silica micro-shells were driven to the surface of the film. The air sealed in the hollow space of the silica shells acted as an ultrasound contrast agent and echo decorrelation of air exposed to ultrasound waves produces color Doppler signals.

Ultrasound responsive micro-composite markers

A composition for coating a medical device and a coated medical device are provided. The composition includes a polymeric matrix having non-toxic quantum dots or a fluorophore or both. The polymeric matrix contains the quantum dots or fluorophore and binds as a coating to the medical device. Coated medical devices can be readily identified within or outside of a body and in open or laparoscopically surgeries, greatly reducing or eliminating the risk of a retained foreign object.

Fluorescent and/or NIR coatings for medical objects, object recovery systems and methods

Disclosed herein is an ultrasound imaging apparatus and a controlling method thereof. The ultrasound imaging apparatus includes a controller configured to generate a control signal to control an operation of a probe, and a transceiver configured to transmit the control signal to the probe and to receive a signal transmitted from the probe. The controller may control the operation of the probe so that the probe may irradiate focused ultrasound energy when contrast agents composed of a silica nanostructure are injected into an object, and the controller may control the operation of the probe so that the probe may irradiate diagnostic ultrasound energy when the focused ultrasound energy is irradiated.

Probe, ultrasound imaging apparatus and controlling method of the ultrasound imaging apparatus

A composition is provided which comprises a recombinant viral particle comprising a capsid, wherein the viral particle is encapsulated into an anionic liposome comprising lecithin and polyethylene glycol (PEG). A method for preparing and purifying the encapsulated viral particles is provided as well. Methods for treating patients by using the encapsulated viral particles are provided as well.

Composition of viral vectors in lecithin liposomes, preparation method and treatment methods

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La Jolla, CA, United States of America

Sarah L Blair