Epizyme, Inc.

Eisai R&d Management Co., Ltd.

Sarah Kathleen Knutson

Heike Keilhack

Kevin Wayne Kuntz

Natalie Warholic

Richard Chesworth

Kenneth William Duncan

Masashi Seki

Christine Klaus

Syuji Shirotori

Satoshi Kawano

Timothy James Nelson Wigle

Timothy J N Wigle

Victoria M Richon

Roy MacFarlane Pollock

Danielle Johnston Blackwell

Christopher J Sneeringer

Robert A Copeland

Margaret D Scott

Larisa Reyderman

Lone Ottesen

L Danielle Johnston

Timothy James Wigle

Danielle L Johnston

Robert Allen Copeland

Margaret Davis Scott

Victoria Marie Richon

Christopher John Sneeringer

Roy Macfarlane Pollock

The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

Aryl-OR heteroaryl-substituted benzene compounds

Aryl-or heteroaryl-substituted benzene compounds

The present invention relates to methods of treating cancer by administering the EZH2 inhibitor compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

Methods of treating cancer

The present disclosure relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.

EZH2 inhibitors for treating lymphoma

The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and their use for the treatment of cancer.

The present disclosure relates to pharmaceutical compositions comprising inhibitor(s) of human histone methyltransferase EZH2, and methods of cancer therapy using the EZH2 inhibitor(s).

Method for treating cancer

The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.

Combination therapy for treating cancer

Growing community of inventors

Cambridge, MA, United States of America

Sarah Kathleen Knutson