Miltenyi Biotech B.v. & Co. Kg

Miltenyi Biotec, Gmbh

Dübel, Stefan

Sarah-Jane Kellmann

Stefan Dübel

Holger Thie

The present invention provides a composition comprising i) a polypeptide comprising calmodulin and two immunoglobulin superfamily domains, wherein said two immunoglobulin superfamily domains are linked via said calmodulin; ii) a calmodulin binding molecule; iii) ions binding to the Cabinding site of calmodulin; wherein the binding of said calmodulin-binding molecule and of said ions to said Cabinding site of calmodulin affects the binding of said polypeptide to an antigen to be bound by said polypeptide. The calmodulin may be a permutated calmodulin. A method for affecting the binding of a polypeptide for an antigen using said composition is also disclosed.

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Gummersbach, Germany

Sarah-Jane Kellmann