University of Nebraska

University of Iowa Research Foundation

Sarah Holstein

David Wiemer

Disclosed herein are inhibitors of the GGDPS enzyme, and methods for their use in treating or preventing diseases, such as multiple myeloma. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are described.

Triazole bisphosphonate geranylgeranyl diphosphate synthase inhibitors

Disclosed herein are inhibitors of the GGDPS enzyme, and methods for their use in treating or preventing diseases, such as multiple myeloma. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are described. 

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Omaha, NE, United States of America

Sarah Holstein