Isis Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc.

The University of British Columbia

Sarah Greenlee

Susan M Freier

C Frank Bennett

Eric E Swayze

Thazha P Prakash

Michael R Hayden

Zhengrong Yu

Jeffrey Carroll

Simon Warby

John E Matson

Disclosed herein are antisense compounds and methods for selectively reducing expression of an allelic variant of a gene containing a single nucleotide polymorphism (SNP). Such methods, compounds, and composition are useful to treat, prevent, or ameliorate diseases, including neurodegenerative diseases, such as Huntington's Disease (HD).

Selective reduction of allelic variants

The present invention provides methods of detecting and/or quantitating a target oligonucleotide in a biological sample.

Compounds and methods for detecting oligonucleotides

Disclosed herein are antisense compounds and methods for selectively reducing expression of an allelic variant of a huntingtin gene containing a single nucleotide polymorphism (SNP). Such methods, compounds, and composition are useful to treat, prevent, or ameliorate Huntington's Disease (HD).

Disclosed herein are antisense compounds and methods for selectively of reducing expression of an allelic variant of a gene containing a single nucleotide polymorphism (SNP). Such methods, compounds, and composition are useful to treat, prevent, or ameliorate diseases, including neurodegenerative, such as Huntington's Disease (HD).

Growing community of inventors

San Diego, CA, United States of America

Sarah Greenlee