Northwestern University

Case Western Reserve University

Sarah Grace Kamper

Thomas J Meade

James P Basilion

Kirti Dhingra

Provided herein are MRI contrast agents that are conditionally activated by an enzyme from a reporter gene coupled to a gene of interest. In some embodiments, provided herein is a platform where a substrate (blocking access of water to a Gd(III) ion) is removed by an enzyme that can be changed to accommodate a number of gene therapy targets.

Bio-activated reporters to visualize, in real time, specific gene therapy products

A composition for imaging a cell includes a first imaging probe and a second imaging probe that include respectively a first reporter moiety and a second reporter moiety. The first reporter moiety and the second reporter moiety form a signaling complex that produces a detectable signal when the first imaging probe and second imaging probe complex with first and second biomarkers of the cell.

Growing community of inventors

Evanston, IL, United States of America

Sarah Grace Kamper