Tmem16a Limited

Sarah Ellam

Edward Walker

Clive Mccarthy

Jonathan David Hargrave

Duncan Alexander Hay

Thomas Beauregard Schofield

Christopher Charles Stimson

Stephen Collingwood

Peter Neville Ingram

Abdul Kadar Shaikh

Matthew Raymond Smith

Craig Stephen Buxton

Matthew Habgood

Spencer Charles Robert Napier

Chun Yan Ma

Spencer Napier

Compounds of general formula (I): wherein R, R, R, R, R, RX, X, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

Compounds

Compounds of general formula (I): wherein R, R, R, R, R, R* X, X, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions. 

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Didcot, United Kingdom

Sarah Ellam