Theravance, Inc.

Theravance Respiratory Company, LLC

Sarah Dunham

Mathai Mammen

Adam D Hughes

Craig Husfeld

Li Li

Eric L Stangeland

Yu-Hua Ji

Trevor Mischki

YongQi Mu

Aaron Kushner

Yan Chen

Yuhua Ji

Richard D Wilson

Ioanna Stergiades

David A Oare

Tae Weon Lee

This invention provides biphenyl derivatives of formula I: 

Biphenyl derivatives

The invention provides compounds of formula I: wherein a, b, c, m, s, t, W, Z, Ar, R, R, R, R, and Rare as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Biphenyl compounds useful as muscarinic receptor antagonists

The invention is directed to compounds of formula I: 

Compounds having BETA2 adrenergic receptor agonist and muscarinic receptor antagonist activity

This invention provides 4-amino-1-benzylpiperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome, asthma and chronic obstructive pulmonary disease, using such compounds.

Substituted 4-amino-benzylpiperidine compounds

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Substituted 4-amino-1-benzylpiperidine compounds

This invention provides 4-amino-1-(pyridylmethyl)piperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome and chronic obstructive pulmonary disease, using such compounds.

Substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds

This invention provides compounds of formula I: wherein a, b, c, e, m, R, R, R, R, R, R, R, R, and Rare as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Diphenylmethyl compounds useful as muscarinic receptor antagonists

This invention provides compounds of formula I: wherein a, b, c, e, m, R, R, R, R, R, R, R, Rand Rare as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

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South Yarra, Australia

Sarah Dunham