Duke University

Sarah Dicker

Thorsten M Seyler

Brian Allen

Catherine Oliver

Ken Gall

Kenneth A Gall

A method includes forming a mixture including a therapeutic agent and a solid delivery medium, injecting the mixture into a reservoir within an orthopedic implant body, and storing the injected mixture in the reservoir.

Orthopedic implant for sustained drug release

An orthopedic implant device has a bone-replacement contour that replicates a healthy bone surface contour. An exterior surface of the device has elution pores. Interior surfaces of the device define a reservoir that is spaced inward from the exterior surface. The reservoir stores a therapeutic agent delivery medium impregnated with a therapeutic agent. The interior surfaces further define elution channels communicating the reservoir with the elution pores to convey a therapeutic agent from the reservoir to the exterior surface. A solid therapeutic agent delivery medium is stored in the reservoir, and is biodegradable under the influence of synovial fluid.

Growing community of inventors

Potomac, MD, United States of America

Sarah Dicker