New York Blood Center, Inc.

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Sara Lustigman

Angus J MacDonald

Ehud Ben-Hur

Thomas B Nutman

Sasisekhar Bennuru

Paul Gottlieb

Angus J Macdonald

Disclosed herein are immunogenic compositions for preventing or treating infection with filarial parasites and biomarkers for diagnosing infection with filarial parasites.

Biomarkers and immunogenic compositions for filarial parasites

The present disclosure relates to a method for inducing an antigen-specific immune response to an antigen in a mammal in need thereof, or potentiating an immune response, by administering to the mammal an effective amount of an isolated Ov-ASP, or at least one subunit of Ov-ASP.

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The present invention relates to a method for potentiating a specific immune response to an antigen in a mammal in need thereof. The method comprises administering to the mammal an effective amount of Ov-ASP, or at least one subunit of Ov-ASP, and an antigenic moiety.

Methods of use of phthalocyanines to inactivate blood borne parasites

This invention relates to a method for inactivating parasites in blood cell-containing compositions by incubating a mixture of the blood cell-containing composition, a phthalocyanine dye and a quencher and optionally irradiating this mixture with red light. This invention further relates to a method of sterilizing blood cell-containing compositions which contain lipid enveloped viruses and blood borne parasites.

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New York, NY, United States of America

Sara Lustigman