Rutgers, the State University of New Jersey

Biodelivery Sciences International, Inc.

University of Medicine and Dentistry of New Jersey

Sara L Krause-Elsmore

Raphael J Mannino

Susan Gould-Fogerite

Ruying Lu

David Delmarre

Patrick L Ahl

Gaofeng Shang

Zi Wei Chen

Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.

Encochleation methods, cochleates and methods of use

The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for later addition of cargo moieties are also contemplated.

Geodate delivery vehicles

Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.

Cochleate compositions directed against expression of proteins

Growing community of inventors

Kearny, NJ, United States of America

Sara L Krause-Elsmore