University of Texas System

Sara Chirayil

A Dean Sherry

Veronica Clavijo Jordan

Christian Preihs

Jing Yu

Andre F Martins

Yunkou Wu

Khaled Nasr

Maria Veronica Clavijo Jordan

In some aspects, the present disclosure provides gadolinium based sensors which may be used to image zinc ions in vivo. In some embodiments, the compounds show appropriate reactivity with zinc ions while maintaining high relaxivity to achieve improved background relative to other sensors.

Zinc sensors for in vivo imaging of beta-cell function by MRI

In some aspects, the present disclosure provides compounds of the formula: wherein the variables are defined herein. In some aspects, the present disclosure provides methods of preparing imaging agents, compositions thereof, and methods of imaging using said imaging agents or compositions thereof.

Mn(II)-based sensors to detect zinc in vivo with MRI

In some aspects, the present disclosure provides novel ligands, which may be used to make novel MRI contrast agents for the detection of zinc. In further aspects, by the present disclosure also provides methods of using as imaging agents and compositions thereof.

Gadolinium-based contrast agents for sensitive detection of Znwith MRI

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Plano, TX, United States of America

Sara Chirayil