British American Tobacco (Investments) Limited

British American Tobacco Limited

Sara Ben Khaled

Francisco Anastacio De Abreu E Lima

The present invention provides a method for modulating the alkaloid content of a plant (e.g. a tobacco plant), the method comprising modifying said plant by modulating the activity or expression of at least one protein kinase. The present invention also provides for the use of at least protein kinase gene for modulating the alkaloid content of a plant, as well as tobacco cells, plants, plant propagation materials, harvested leaves, processed tobaccos, or tobacco products obtainable in accordance with the invention.

Method of modulating the alkaloid content of a plant

The present invention provides a method for modulating (e.g. decreasing) the alkaloid content of a plant (e.g. a tobacco plant), the method comprising modifying said plant by modulating the activity or expression of at least one gene encoding a SOUL haem-binding protein. The present invention also provides for the use of at least one gene encoding a SOUL haem-binding protein for modulating the alkaloid content of a plant, as well as tobacco cells, plants, plant propagation materials, harvested leaves, processed tobaccos, or tobacco products obtainable in accordance with the invention.

Method for decreasing the alkaloid content of a tobacco plant

The present invention relates to a method of modulating the alkaloid content of a plant or a part thereof, the method comprising modifying the plant by modulating the activity or expression of at least one gene encoding an RNA binding protein. The present invention also relates to a method of reducing the content of at least one tobacco specific nitrosamine (TSNA) precursor in tobacco, the method comprising modulating the activity or expression of at least one gene encoding an RNA binding protein.

Method for modifying alkaloid content in plants

The present invention provides a method for modulating (e.g. decreasing) the alkaloid content of a plant (e.g. a tobacco plant), the method comprising modifying said plant by modulating (e.g. decreasing) the expression of at least one armadillo repeat protein. The present invention also provides for the use of an armadillo repeat protein for modulating the alkaloid content of a plant, as well as tobacco cells, plants, plant propagation materials, harvested leaves, processed tobaccos, or tobacco products obtainable in accordance with the invention.

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London, United Kingdom

Sara Ben Khaled