Advinus Therapeutics Private Limited

Impetis Biosciences Limited

Santosh Kurhade

Debnath Bhuniya

Kasim A Mookhtiar

Anil M Deshpande

Balasaheb Kobal

Sachin Kandalkar

Venkata Poornapragnacharyulu Palle

Bheemashankar A Kulkarni

Bhavesh Dave

Sandeep Bhausaheb Bhosale

Vinod Vyavahare

Summon Koul

Keshav Naik

Kasim Mookhtiar

Yogesh Munot

Siddhartha De

Gobind Sing Kapkoti

Mahesh Thakkar

Tanaji Mengawade

Rahul Kaduskar

Anil Deshpande

Debanath Bhuniya

Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed.  The disclosure also provides process of preparation of these acetamide derivatives.

Acetamide derivatives as glucokinase activators, their process and medicinal applications

The present disclosure provides hetero-bicyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, hydrates, N-oxides, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by Bruton's tyrosine kinase (Btk) activity, The disclosure also relates to the process of preparation of compounds of Formula (I).  These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of Bruton's tyrosine kinase (Btk), such as inflammatory and/or autoimmune disorder, cell proliferation, rheumatoid arthritis, psoriasis, psoriatic arthritis, transplant rejection, graft-versus-host disease, multiple sclerosis, inflammatory bowel disease, allergic diseases, asthma, type 1 diabetes, myasthenia gravis, hematopoetic disfunction, B-cell malignancies, systemic lupus, erythematosus or other disorders.

Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof

Acetamide derivatives as glucokinase activators, their process and medicinal application

Growing community of inventors

Maharashtra, India

Santosh Kurhade