Council of Scientific and Industrial Research

Santosh Kumar Srivastava

Suman Preet Singh Khanuja

Merajuddin Khan

Madan Mohan Gupta

Anirban Pal

Dharmendra Saikia

Ram Kishor Verma

Subash Chandra Verma

Ajit Kumar Shasany

Mahendra Pandurang Darokar

Tiruppadiripuliyur Ranganathan Santha Kumar

Anil Kumar Gupta

Monika Singh

Subhash Chandra Gupta

Chandeshwar Nath

Ankur Garg

Subhash Chandra Singh

Digvijay Singh

Janardan Singh

Mahendra Pandurang Dardokar

Anupam Maurya

Dnyaneshwar Umrao Bawankule

Shikha Gupta

Ankur Grag

Raghavendra Kumar Mishra

Subash Chandra Singh

Vinay Kumar Khanna

Ashok Kumar Agrawal

Ranganathan Santha Kumar Tiruppadiripuliyur

Harpreet Kaur

Jai Shanker Arya

The present invention relates to bioactive extracts its fractions and isolation of compound from. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D, Cholinergic (muscarinic) and Serotonergic (5HT) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-demethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and &#x3b1;-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkaloids of formula 1 and 2 from the leaves of. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions ofand in the isolated compounds &#x3b1;-yohimbine, reserpiline and in a mixture 10-demethoxyreserpiline and 11-demethoxyreserpiline in 1:1.5 ratios for treating psychosis without any extra pyramidal symptoms (EPS). 

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The present invention provides novel loganin analogues and a process for the preparation thereof. The present invention further provides the use of Iridoid glycoside loganin isolated from the fruit pulp of-and its bioactive semi-synthetic analogues against various human cancer cell lines grown in-vitro.

Loganin analogues and a process for the preparation thereof

The present invention provides an improved process for the isolation of oleane compounds from the bark of(Roxb.). More particularly, the present invention relates to an improved process for the isolation of arjunic acid and its derivates from the bark of(Roxb.). The present invention further provides the identification of arjunic acid [1] and its derivatives as anticancer agent useful in the treatment of various types of cancer in humans.

Process for the isolation of oleane compounds isolated from the bark of arjun tree terminalia arjuna (Roxb.)

The present invention relates to an improved and economical process for the isolation of anticancer agent Camptothecin from the twigs and stem ofusing hot extraction 20(S) Camptothecin is an alkaloid, which contains a pentacyclic ring system that includes a pyrrolo [3,4-b] quinoline moiety (ring A, B and C), the pyridone ring D and a chiral center at C-20 in ring E.

Process for isolation of anticancer agent camptothecin from Nothapodytes foetida

Accordingly the present invention provides an improved and economical process for the isolation of oleanolic acid from the roots of, which comprises of drying, grinding and defattening ofroots with light petroleum followed by over night extractions at room temperature (30-40&#xb0; C.) three times with a single solvent selected from CHCl, CHCl, EtOAc, ether, acetone, MeOH, EtOH etc., removal of solvent under vacuum at 35-45&#xb0; C., precipitation of crude extract and repeated partial crystallization of precipitate with a single solvent selected from CHCl, CHCl, EtOAc, ether, acetone, MeOH, EtOH, HO and others resulting in the isolation of oleanolic acid with 1% yield.

Process for isolation of hepatoprotective agent 'oleanolic acid' from Lantana camera

The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods ofThe present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (&#x2212;) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.

Nitrile glycoside useful as a bioenhancer of drugs and nutrients, process of its isolation from moringa oleifera

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Lucknow, India

Santosh Kumar Srivastava