University of Connecticut

Santosh Keshipeddy

Dennis L Wright

Michael Henry Cynamon

Amy C Anderson

Eric William Scocchera

Stephanie Reeve

Royce Mohan

Narendran Gummudipundi Dayanandan

Michael N Lombardo

Paola Bargagna-Mohan

Eric Scocchera

Dennis Wright

Narendran Gummudipundi Dayanan

The disclosure provides compounds of the formula I and the pharmaceutically acceptable salts thereof. The variables, e.g. R, R, R, R, A, B, J, V, W, M, J and Ar are defined herein. The disclosure also provides pharmaceutical compositions comprising a compound or salt of formula I and a pharmaceutically acceptable carrier, methods of inhibiting dihydrofolate reductase (DHFR) in vitro or in vivo with a compound or salt of formula I, and methods of treating a bacterial infections, fungal infections, and protozoal infections with a compound or salt of formula I. A compound or salt of formula I can be the first and only active ingredient used in a pharmaceutical composition or method of this disclosure or may be combined with one or more additional active ingredients that are not compounds or salts of formula I.

Zwitterionic propargyl-linked antifolates useful for treating bacterial infections

The present disclosure relates to compounds and methods for labeling and/or detecting proteins in vivo, and methods for probing mitochondrial structure and/or dynamics.

Methods of use for intermediate filament protein probes

Growing community of inventors

Hamden, CT, United States of America

Santosh Keshipeddy