University of California

Myeloid Therapeutics, Inc.

The Brigham and Women's Hospital, Inc.

Santosh Kesari

Wolfgang J Wrasidlo

Milan T Makale

Amit N Patel

Boris Minev

Olivia A Graeve

Joanna McKittrick

Samuel C Wagner

Gustavo A Hirata Flores

Thomas E Ichim

Julia S Szymanski

Anna M Krichevsky

Nadiya Teplyuk

Brit Mollenhauer

Rajesh Mukthavaram

There are provided, inter alia, compositions including a scintillator nanocrystal linked to a chemical agent moiety through a scintillator-activated photocleavable linker, and methods of use thereof.

Scintillator nanocrystal-containing compositions and methods for their use

The current invention provides monocytic cells transfected with chimeric antigen receptor (CAR) to selectively home to tumors and upon homing differentiate into dendritic cells capable of activating immunity which is inhibitory to said tumor. In one embodiment of the invention, monocytic cells are transfected with a construct encoding an antigen binding domain, a transcellular or structural domain, and an intracellular signaling domain. In one specific aspect of the invention, the antigen binding domain interacts with sufficient affinity to a tumor antigen, capable of triggering said intracellular domain to induce an activation signal to induce monocyte differentiation into DC.

Chimeric antigen receptor dendritic cell (CAR-DC) for treatment of cancer

Provided herein are compositions methods of using liposomally encapsulated therapeutic drugs, such as staurosporine. Further provided herein are methods of using the liposome compositions to treat a cancer.

Liposomal drug encapsulation

The use of specific microRNAs (miRNAs) present in CSF as biomarkers for particular brain malignancies and disease activity.

Diagnosing and monitoring CNS malignancies using microRNA

Diagnosing and monitoring CNS malignancies using MicroRNA

Growing community of inventors

San Diego, CA, United States of America

Santosh Kesari