Janssen Biotech, Inc.

Aligos Therapeutics, Inc.

Santhosh Kumar Thatikonda

Leonid Beigelman

James Patrick Edwards

Peter J Connolly

Guangyi Wang

Stuart Emanuel

Gilles C Bignan

Mark Richter

Minghong Zhong

Marcel Viellevoye

Tianbao Lu

Antitsa Dimitrova Stoycheva

Sylvie Laquerre

Johannes Wilhelmus John Fitzgerald Thuring

Wim Schepens

Wim Bert Griet Schepens

Johannes Wilhelmus J F Thuring

Sylvia Laquerre

Wim Gert Griet Schepens

Provided herein are compounds of Formula (I), Formula (II) and/or Formula (III), or pharmaceutically acceptable salts of any of the foregoing, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), Formula (II) and/or Formula (III), or a pharmaceutically acceptable salt of any of the foregoing.

Modified cyclic dinucleoside compounds as sting modulators

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I), wherein R, R', X, B, R, R&#x2032;, B, X, R, Z-M-Y, and Y-M-Zare as defined herein. 

Cyclic dinucleotides as sting agonists

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R, R, R, R, R, B, W, X, Y, Z are defined herein.

Disclosed are compounds, compositions and methods for treating viral infections, diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R, R, R, B, R, and Rare defined herein.

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows:  wherein R, R, R, and Rare defined herein.

Growing community of inventors

Fremont, CA, United States of America

Santhosh Kumar Thatikonda