Creighton University

Ting Therapeutics LLC

St. Jude Children's Research Hospital, Inc. (tennessee Not for Profit Corporation)

Santanu Hati

Jian Zuo

Marisa Laura Zallocchi

Jaeki Min

Jeff North

Robert Hazlitt

In one aspect, use of compounds as active agents to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. (E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-S,6-dihydropyridin-2(1H)-one and derivatives exhibit excellent protection against antibiotic-induced hearing loss in zebrafish and mice. In one aspect, (E)-1-(3-(3,4,5-trimethoxy phenyl)acryloyl)-S,6-dihydropyridin-2(1H)-one and derivatives can be used as a therapy for the treatment and/or prevention of hearing loss. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Compositions and methods for the prevention and treatment of hearing loss

Provided are CDK2-PROTAC compounds and pharmaceutical compositions thereof that can be used for specific degradation of the cyclin-dependent kinase 2 (CDK2) protein, for treatment of cancers and other CDK2 related diseases as well as for prevention and treatment of hearing loss.

Compositions, use, and method for CDK2-PROTACs for cancer therapy and hearing loss

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Omaha, NE, United States of America

Santanu Hati