Distretto Tecnologico Sicilia Micro E Nano Sistemi S.c.a.r.l.

Consiglio Nazionale Delle Ricerche

Sifi S.p.a.

Santa Viola

Gaetano Giammona

Giovanna Pitarresi

Salvatore Cuzzocrea

Anna Rita Blanco

Salvatore Papasergi

Mariano Licciardi

Patrizia Saladino

Gennara Cavallaro

Sandro De Falco

Maria Grazia Mazzone

Grazia Maria Letizia Consoli

Maria Cristina Curatolo

Patrizia Guarneri

Emanuela Fabiola Craparo

Emanuela Esposito

Maria Luisa Bondi'

Guiseppe Granata

Clara La Marca

Elena Solfato

Ilenia Abbate

Cristina Maria Concetta Zappulla

Manuela Santonocito

Irene Ceidda

Francesco Giuliano

Maria Luisa Bondi′

Irene Deidda

Clara La Marco

Giuseppe Granata

Donato Spina

Veronica Pepe

Angelo Pricoco

Giuseppe De Pasquale

Francesco Cuffari

Luca Rosario La Rosa

Maria Luisa Bondi

Andrea Sudano Roccaro

Carmela Giovanna Spoto

Provided are oil-in-water microemulsions for formulating pharmaceutically active compounds. The microemulsions contain oils, surfactants, water, and the pharmaceutical compounds, and are produced by mixing an aqueous phase and a lipid phase in which each phase contains at least one surfactant in a defined ratio whereby the resulting microemulsion has very small dispersed particles and is thermodynamically very stable.

Microemulsion compositions

Formulations are described, containing silibinin or other active ingredients incorporated in lipid nanoparticle systems of the SLN and NLC type, and based on calixarenes, possibly mucoadhesive, or in micellar and nanoparticle systems based on amphiphilic inulin copolymers for use in the treatment of neurodegenerative ocular diseases. The versatility of the calixarene compound is also described, capable of charging and releasing active ingredients characterized by low water solubility, easy chemical and enzymatic degradation, low bioavailability, either of natural origin or not, to be used in the treatment of ocular diseases.

Nanostructured formulations for the delivery of silibinin and other active ingredients for treating ocular diseases

Provided are oil-in-water microemulsions for formulating pharmaceutically active compounds. The microemulsions contain oils, surfactants, water, and the pharmaceutical compounds, and are produced by mixing an aqueous phase and a lipid phase in which each phase contains at least one surfactant in a defined ratio whereby the resulting microemulsion has very small dispersed particles, and, is thermodynamically very stable.

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Paterno, Italy

Santa Viola