Distretto Tecnologico Sicilia Micro E Nano Sistemi S.c.a.r.l.

Consiglio Nazionale Delle Ricerche

Sifi S.p.a.

Santa Viola

Salvatore Cuzzocrea

Giovanna Pitarresi

Gaetano Giammona

Anna Rita Blanco

Emanuela Esposito

Patrizia Guarneri

Salvatore Papasergi

Patrizia Saladino

Mariano Licciardi

Emanuela Fabiola Craparo

Grazia Maria Letizia Consoli

Sandro De Falco

Maria Grazia Mazzone

Maria Cristina Curatolo

Gennara Cavallaro

Elena Solfato

Francesco Giuliano

Manuela Santonocito

Cristina Maria Concetta Zappulla

Ilenia Abbate

Clara La Marca

Guiseppe Granata

Irene Ceidda

Maria Luisa Bondi'

Maria Luisa Bondi′

Clara La Marco

Giuseppe Granata

Irene Deidda

Maria Luisa Bondi

Luca Rosario La Rosa

Francesco Cuffari

Donato Spina

Grazia Maria Consoli

Giuseppe De Pasquale

Angelo Pricoco

Veronica Pepe

Carmela Giovanna Spoto

Andrea Sudano Roccaro

Provided are oil-in-water microemulsions for formulating pharmaceutically active compounds. The microemulsions contain oils, surfactants, water, and the pharmaceutical compounds, and are produced by mixing an aqueous phase and a lipid phase in which each phase contains at least one surfactant in a defined ratio whereby the resulting microemulsion has very small dispersed particles and is thermodynamically very stable.

Microemulsion compositions

Formulations are described, containing silibinin or other active ingredients incorporated in lipid nanoparticle systems of the SLN and NLC type, and based on calixarenes, possibly mucoadhesive, or in micellar and nanoparticle systems based on amphiphilic inulin copolymers for use in the treatment of neurodegenerative ocular diseases. The versatility of the calixarene compound is also described, capable of charging and releasing active ingredients characterized by low water solubility, easy chemical and enzymatic degradation, low bioavailability, either of natural origin or not, to be used in the treatment of ocular diseases.

Nanostructured formulations for the delivery of silibinin and other active ingredients for treating ocular diseases

Provided are oil-in-water microemulsions for formulating pharmaceutically active compounds. The microemulsions contain oils, surfactants, water, and the pharmaceutical compounds, and are produced by mixing an aqueous phase and a lipid phase in which each phase contains at least one surfactant in a defined ratio whereby the resulting microemulsion has very small dispersed particles, and, is thermodynamically very stable.

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Paterno, Italy

Santa Viola